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Methylphenidate

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MPH
Methylphenidate
Molecular structure via molpic based on CDK
Physical properties
[]
233.31 g/mol [1]
AppearanceCrystals from ethanol (aqueous) [1]
Melting point74-75 °C [1]
Boiling pointBP: 135 to 137 °C at 0.6 mm Hg [1]
DecompositionWhen heated to decomposition it emits toxic fumes of nitroxides. [1]
Solubility1255mg/L [1]
0.2 [1]
Structural Identifiers
[]
C14H19NO2 [1]
methyl 2-phenyl-2-piperidin-2-ylacetate [1]
COC(=O)C(C1CCCCN1)C2=CC=CC=C2 [1]
InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3 [1]
InChIKeyDUGOZIWVEXMGBE-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life2 – 3 hours
Dosing[]
Buccal
[]
Light≤ 31.6 mg(12x - 33.3%)
Common31.6 - 40 mg(8x - 22.2%)
Strong40 - 60 mg(10x - 27.8%)
Heavy60 - 85 mg(2x - 5.6%)
Extreme85 mg +(4x - 11.1%)
Insufflated
[]
Light≤ 32.7 mg(76x - 30.4%)
Common32.7 - 40 mg(64x - 25.6%)
Strong40 - 60 mg(49x - 19.6%)
Heavy60 - 116.3 mg(35x - 14%)
Extreme116.3 mg +(26x - 10.4%)
Intravenous
[]
Light≤ 8.8 mg(1x - 25%)
Common8.8 - 10 mg(2x - 50%)
Strong10 - 15 mg
Heavy15 - 24 mg
Extreme24 mg +(1x - 25%)
Subcutaneous
[]
Light≤ 40.9 mg(2x - 66.7%)
Common40.9 mg
Strong40 - 50 mg
Heavy50 - 56 mg
Extreme56 mg +(1x - 33.3%)
Sublingual
[]
Light≤ 34.5 mg(74x - 27.2%)
Common34.5 - 40 mg(80x - 29.4%)
Strong40 - 60 mg(53x - 19.5%)
Heavy60 - 98 mg(37x - 13.6%)
Extreme98 mg +(28x - 10.3%)
Oral
[]
Light≤ 24.8 mg(122x - 43.1%)
Common24.8 - 36 mg(37x - 13.1%)
Strong36 - 72 mg(57x - 20.1%)
Heavy72 - 108 mg(40x - 14.1%)
Extreme108 mg +(27x - 9.5%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Methylphenidate (also known as Methylphenidan, Phenidylate, Calocain, Plimasine, Methyl phenidylacetate, Metilfenidato, Methylphenidatum, Methyl phenidate, 4311/B Ciba or Daytrana) is a stimulant substance of the phenidate class.

Chemistry

 []

Methylphenidate is a racemic mixture of the .

(4S,5S)-MethylphenidateGenerated by the Chemistry Development Kit (http://github.com/cdk)
(4R,5S)-MethylphenidateGenerated by the Chemistry Development Kit (http://github.com/cdk)
(4S,5R)-MethylphenidateGenerated by the Chemistry Development Kit (http://github.com/cdk)
(4R,5R)-MethylphenidateGenerated by the Chemistry Development Kit (http://github.com/cdk)
Stereoisomer enumberation with rdkit

Pharmacology

In the () methylphenidate acts as a stimulant (), sympathomimetic (), methylphenidate () and psychoanaleptic ().[1]

Subjective effects []

class / Stimulant
Mere / Methylphenidate []
magnus / Methylphenidate []
Routes:
  • Oral
  • Insufflated
Salts:
  • Hydrochloride
Effects:
alina / Methylphenidate []
Routes:
  • Insufflated (10.0mg)
  • Oral (5 - 20mg)
bonzi / Methylphenidate []
Routes:
  • Oral (5 - 10mg)
  • Insufflated (5mg)
Pilz / Methylphenidate []
Routes:
  • Oral (5 - 27mg)
Indication:
  • Attention-Deficit/Hyperactivity Disorder
Effects:Notes:
  • Good ADHD-Medication
  • From the available preparations i would recommend concerta/kinecteen
  • Social interactions can feel difficult
emily / Methylphenidate []
Routes:
  • Oral (10 - 50mg)
0xea / Methylphenidate []
Routes:
  • Oral
  • Intravenous
Salts:
  • Hydrochloride
Indication:
  • executive dysfunction
Effects:

Experience reports []

There are currently 25+ experience reports involving methylphenidate on :

=======

There are currently 25+ experience reports involving methylphenidate on :

 []

  • Australia: Methylphenidate is a S8 substance.
  • Brazil: Methylphenidate is a A3 substance.[2]
  • Canada: Methylphenidate is a Schedule III substance.
  • Germany: Methylphenidate is a Anlage III substance.
  • United Kingdom: Methylphenidate is a Class B substance.
  • New Zealand: Methylphenidate is a Class B2 -authority required substance.
  • United States: Methylphenidate is a Schedule I under the "Controlled Substances Act (CSA)".
  • European Union: Methylphenidate is a prescription only substance.
  • United Nations: Methylphenidate is a Schedule II drug under the "Convention on Psychotropic Substances 1971".

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 4158, methylphenidate. Accessed May 8, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/4158

  2. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed May 8, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992