Methylphenidate (MPH)

MPH

Salts []
Hydrochloride

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	233.31 g/mol ^[1]
Appearance	Crystals from ethanol (aqueous) ^[1]
Melting point	74-75 °C ^[1]
Boiling point	BP: 135 to 137 °C at 0.6 mm Hg ^[1]
Decomposition	When heated to decomposition it emits toxic fumes of nitroxides. ^[1]
Solubility	1255mg/L ^[1]
Predicted LogP	0.2 ^[1]

Structural Identifiers []
Molecular formula	C₁₄H₁₉NO₂ ^[1]
IUPAC name	methyl 2-phenyl-2-piperidin-2-ylacetate ^[1]
SMILES	COC(=O)C(C1CCCCN1)C2=CC=CC=C2 ^[1]
InChI	InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3 ^[1]
InChIKey	DUGOZIWVEXMGBE-UHFFFAOYSA-N ^[1]

Dosing []
Elimination half-life	2 – 3 hours

Methylphenidate

Methylphenidate (also known as Methylphenidan, Phenidylate, Calocain, Plimasine, Methyl phenidylacetate, Metilfenidato, Methylphenidatum, Methyl phenidate, 4311/B Ciba or Methyl α-phenyl-α-(2-piperidyl)acetate) is a stimulant substance of the phenidate class.

Chemistry

Salts []

Methylphenidate is typically found in the form of its hydrochloride salt.

Stereochemistry []

Methylphenidate is a mixture

Stereoisomers
Dextromethylphenidate Levomethylphenidate

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Anodyne Usernotes []
0xea / Methylphenidate^{[hydrochloride]} via Oral and Intravenous	Moderate Euphoria; Mild Stimulation; interesting when intravenously injected; Causes Anxiety and Strong Vasoconstriction

Legal status []

Australia: Methylphenidate is a S8 substance.
Brazil: Methylphenidate is a A3 substance.^[2]
Canada: Methylphenidate is a Schedule III substance.
Germany: Methylphenidate is a Anlage III substance.
United Kingdom: Methylphenidate is a Class B substance.
New Zealand: Methylphenidate is a Class B substance.
United States: Methylphenidate is a Schedule I under the "Controlled Substances Act (CSA)".
European Union: Methylphenidate is a prescription only substance.
United Nations: Methylphenidate is a Schedule II drug under the "Convention on Psychotropic Substances 1971".

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 4158, Methylphenidate. Accessed July 13, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/4158
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 13, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992