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Pregabalin

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Pregabalin
Pregabalin
Salts
[]
Pregabalin hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Sodium Pregabalin
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
Conformer structure via 3Dmol.js
Enable javascript to view conformer structure via 3Dmol.js
Physical properties
[]
159.23 g/mol [1]
AppearanceWhite to off-white crystalline solid [1]
Melting point186-188 °C [1]
SolubilityFreely soluble [1]
-1.6 [1]
Structural Identifiers
[]
C8H17NO2 [1]
(3S)-3-(aminomethyl)-5-methylhexanoic acid [1]
CC(C)C[C@@H](CC(=O)O)CN [1]
InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 [1]
InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-N [1]
Pharmacokinetics[]
Elimination half-life4.5 – 7 hours[4] (mean 6.3 hours)[5]
Duration of action8 – 12 hours [6]
Dosing[]
Insufflated
[]
Light≤ 100 mg(79x - 49.1%)
Common100 - 120 mg(8x - 5%)
Strong120 - 150 mg(43x - 26.7%)
Heavy150 - 200 mg(18x - 11.2%)
Extreme200 mg +(13x - 8.1%)
Oral
[]
Light≤ 300 mg(403x - 64.5%)
Common300 mg
Strong300 - 600 mg(145x - 23.2%)
Heavy600 - 750 mg(24x - 3.8%)
Extreme750 mg +(53x - 8.5%)
Intrarectal
[]
Light≤ 700 mg(1x - 50%)
Common700 - 800 mg
Strong800 - 900 mg
Heavy900 - 960 mg
Extreme960 mg +(1x - 50%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Pregabalin (also known as Lyrica, 3-(Aminomethyl)-5-methylhexanoic acid, 3-isobutyl GABA, CI-1008, Pregabaline, Pregabalina, Vronogabic, Pregabalin mylan, Pregabalin sandoz or Pregabalin zentiva) is a substance of the gabapentinoid class.

Chemistry

Salts []

Pregabalin is typically found in the form of its hydrochloride and sodium salts.

 []

Pregabalin is a absolute mixture.

There are currently 11 reagent-interactions on

ReagentColor change
Marquis
Mecke
Mandelin
Liebermann
Froehde
Robadope
Simon's
Ehrlich
Hofmann
Morris
Zimmermann

Pharmacology

In the () pregabalin acts as a analgesic (), gabapentinoid (), other analgesics and antipyretic () and pregabalin ().[1]

Subjective effects []

magnus / Pregabalin []
Routes:
  • Oral (300mg)
Effects:Notes:
  • little effect
alina / Pregabalin []
Routes:
  • Oral (50 - 600mg)
  • Insufflated (80 - 100mg)
bonzi / Pregabalin []
Routes:
  • Oral (50 - 300mg)
x86pup / Pregabalin []
Routes:
  • Oral
  • Intravenous
Pilz / Pregabalin []
Routes:
  • Oral (24 - 300mg)
  • Insufflated (100mg)
Indication:Effects:Notes:
  • Consuming ~120mg daliy since 1-2026 because of stress and
  • Snorting pregabalin is not worth it, but it will have a stronger peak and shorter duration
  • Improves sleep quality
  • Might cause when consumed regularly at higher doses
emily / Pregabalin []
Routes:
  • Oral (18 - 400mg)
  • Insufflated (107mg)
0xea / Pregabalin []
Routes:
  • Oral (150 - 300mg)
  • Intravenous (50 - 110mg)
Salts:
  • Freebase
  • D-Tartrate
Indication:Effects:

Experience reports

Erowid

There are currently 26 experience reports involving pregabalin on : []

 []

  • Australia: Pregabalin is a S4 substance.[3]
  • Brazil: Pregabalin is a C1 substance.
  • Canada: Pregabalin is a prescription only substance.
  • New Zealand: Pregabalin is a prescription only substance.
  • United Kingdom: Pregabalin is a Misuse of Drugs Act 1971|Class C substance.
  • United States: Pregabalin is a Schedule V substance.
  • European Union: Pregabalin is a prescription only substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5486971, Pregabalin. Accessed May 30, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5486971

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pregabalin. UNII: 55JG375S6M. Global Substance Registration System. Accessed May 30, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/55JG375S6M

  3. Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. June 21, 2022. Accessed May 30, 2026. https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017

  4. Expert Committee on Drug Dependence Forty-first Meeting. Critical Review Report: Pregabalin. World Health Organization. November 1, 2018. Accessed May 30, 2026. https://www.who.int/medicines/access/controlled-substances/Pregabalin_FINAL.pdf?ua=1

  5. Cross AL, Viswanath O, Sherman AI. StatPearls [Internet]. StatPearls Publishing. July 19, 2022. Accessed May 30, 2026. https://www.ncbi.nlm.nih.gov/books/NBK470341/

  6. BNF Pregabalin. NICE. November 16, 2018. Accessed May 30, 2026. https://bnf.nice.org.uk/drugs/pregabalin/#indications-and-dose