Anodyne

MPH
Methylphenidate
Salts
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Methylphenidate hydrochloride
Methylphenidate hydrochloride
Molecular structure via molpic
Conformer structure via 3Dmol.js
Molecular formulaC14H19NO2
Molecular mass233.31 g/mol
AppearanceCrystals from ethanol (aqueous)
Predicted LogP0.2
Melting point74-75 °C
Boiling pointBP: 135 to 137 °C at 0.6 mm Hg
DecompositionWhen heated to decomposition it emits toxic fumes of nitroxides.
Solubility1255mg/L
Chiralityracemic
Identifiers
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IUPAC namemethyl 2-phenyl-2-piperidin-2-ylacetate
SMILESCOC(=O)C(C1CCCCN1)C2=CC=CC=C2
InChIInChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3
InChIKeyDUGOZIWVEXMGBE-UHFFFAOYSA-N
Dosing
Elimination half-life2–3 hours
Duration of action
  • IR dosing: 3–4 hours
  • ER dosing: 8–12 hours
Insufflated
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Threshold0.66 - 5 mg
Light5 - 10 mg
Common10 - 20 mg
Strong20 - 40 mg
Heavy40 - 57.60000000000005 mg
Oral
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Threshold1 - 10 mg
Light10 - 18.5 mg
Common18.5 - 40 mg
Strong40 - 60 mg
Heavy60 - 105.00000000000003 mg
Statistically derived dosages by Sernyl

Methylphenidate

Methylphenidate (also known as Methylphenidan, Calocain, Plimasine, Methyl phenidylacetate, Meridil, Methylfenidan, Metilfenidato, Methylphenidatum, Methyl phenidate or 4311/B Ciba) is a stimulant substance of the phenidate class.

Chemistry

Methylphenidate is typically found in the form of its hydrochloride salt.

Stereochemistry

(RS)-Methylphenidate is a racemic mixture of the optical stereoisomers:
Stereoisomers
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Dexmethylphenidate(-)-Methylphenidate
Dexmethylphenidate (-)-Methylphenidate

See also