{"ATC Code":["N - Nervous system","N02 - Analgesics","N02B - Other analgesics and antipyretics","N02BF - Gabapentinoids","N02BF02 - Pregabalin","N03AX16","QN - Nervous system","QN02 - Analgesics","QN02B - Other analgesics and antipyretics","QN02BF - Gabapentinoids","QN02BF02 - Pregabalin"],"Absorption, Distribution and Excretion":"After oral dosing administered in the fasted state, pregabalin absorption is rapid, and extensive. Pregabalin oral bioavailability is reported to be ≥90% regardless of the dose. Cmax is attained within 1.5 hours after single or multiple doses, and steady state is attained within 24-48 hours with repeated administration. Both Cmax and AUC appear to be dose proportional.  Food decreases the rate of pregabalin absorption and as a result, lowers the Cmax by an estimated 25-30% and increases the Tmax to approximately 3 hours. However, the effect of food does not appear to impact the total absorption of pregabalin in a way that is clinically relevant. As a result, pregabalin can be administered with or without food.","Adverse Effects":"Most reported adverse effects caused by pregabalin were mild to moderate intensity, dose-dependent, and occurred within the first 2 weeks of initiating treatment.","Aliases":["Lyrica","3-(Aminomethyl)-5-methylhexanoic acid","3-isobutyl GABA","CI-1008","Pregabaline","Pregabalina","Vronogabic","Pregabalin mylan","Pregabalin sandoz","Pregabalin zentiva","(R-)-3-isobutyl GABA","Pregabalin sandoz gmbh","CI 1008","3-Isobutyl GABA","LYRICA CR","YNP-1807","NSC-759256","Hexanoic acid, 3-(aminomethyl)-5-methyl-, (S)-","Pregabalin mylan pharma","Dtxcid9025950","Chebi:64356","pregabalinum","Lecaent","Rewisca","Alzain","Axalid","3-(aminomethyl)-5-methyl-hexanoic acid","3 isobutyl GABA","GABA, 3-isobutyl","BONQAT","(S+)-3-isobutyl GABA","Pregabalin Extended Release","PREGABALIN capsules, CV","N03AX16","CI1008","1008, CI","604-639-1","NSC729898","Hexanoic acid, 3-(aminomethyl)-5-methyl-, (3S)-","(3S)-3-(aminomethyl)-5-methyl-hexanoic acid","CHEMBL1059","Nervalin","Pregablin","Pregabalin CRS","HSDB 7530","Ncgc00095186-01","3-aminomethyl-5-methylhexanoic acid","3-(Aminomethyl)-5-methylhexanoicacid","Schembl8227","Pregabalin Impurity Standard","orb389663","(+)-4-amino-3-(2-methylpropyl)butanoic acid","GTPL5484","DEA No. 2782","Pregabalin, 1mg/ml in Methanol","GLXC-07956","HMS3715J16","Pregabalin 1.0 mg/ml in Methanol","Tox21_111475","Bdbm50164279","Mfcd00917044","Akos001476611","Akos005145504","Lyrica;CI-1008;PD-144723","AC-1158","CCG-221247","CS-1247","DB00230","KS-5378","NSC 759256","Ncgc00095186-06","Ncgc00095186-11","Ncgc00346738-01","121GE001","HY-17414","3-Aminomethyl-5-methyl-hexanoic acid","Cas-148553-50-8","NS00000537","P2840","P7118","(+)-3-Aminomethyl-5-Methylhexanoic Acid","D02716","Ab01563007_01","F418830","Q412174","Sr-01000942257","Hexanoic acid, 3-(aminomethyl)-5-ethyl-, (3S)-","Q-201617","Sr-01000942257-2","Brd-k66786476-001-01-3","Brd-k66786476-003-01-9","Pregabalin, EuropePharmacopoeia (EP) Reference Standard","Pregabalin Working Standard","1414928-41-8"],"Biological Half-Life":"The elimination half life of pregabalin is 6.3 hours.","CAS":"148553-50-8","ChemicalClasses":["gabapentinoid"],"Chirality":"absolute","Color/Form":"White to off-white crystalline solid","DBI-IGS":["Pregabalin"],"DTXSID":"1045950","Dosing Info":[{"Method":"Insufflated","Tiers":{"Common":{"Entries":8,"Lower":100,"Percentage":5,"Unit":"mg","Upper":120},"Extreme":{"Entries":13,"Lower":200,"Percentage":8.1,"Unit":"mg","Upper":200},"Heavy":{"Entries":18,"Lower":150,"Percentage":11.2,"Unit":"mg","Upper":200},"Light":{"Entries":79,"Lower":100,"Percentage":49.1,"Unit":"mg","Upper":100},"Strong":{"Entries":43,"Lower":120,"Percentage":26.7,"Unit":"mg","Upper":150}}},{"Method":"Oral","Tiers":{"Common":{"Entries":0,"Lower":300,"Percentage":0,"Unit":"mg","Upper":300},"Extreme":{"Entries":53,"Lower":750,"Percentage":8.5,"Unit":"mg","Upper":750},"Heavy":{"Entries":24,"Lower":600,"Percentage":3.8,"Unit":"mg","Upper":750},"Light":{"Entries":403,"Lower":300,"Percentage":64.5,"Unit":"mg","Upper":300},"Strong":{"Entries":145,"Lower":300,"Percentage":23.2,"Unit":"mg","Upper":600}}},{"Method":"Intrarectal","Tiers":{"Common":{"Entries":0,"Lower":700,"Percentage":0,"Unit":"mg","Upper":800},"Extreme":{"Entries":1,"Lower":960,"Percentage":50,"Unit":"mg","Upper":960},"Heavy":{"Entries":0,"Lower":900,"Percentage":0,"Unit":"mg","Upper":960},"Light":{"Entries":1,"Lower":700,"Percentage":50,"Unit":"mg","Upper":700},"Strong":{"Entries":0,"Lower":800,"Percentage":0,"Unit":"mg","Upper":900}}}],"Drug Classes":["Breast Feeding","Lactation","Milk, Human","Analgesics","Anticonvulsants"],"Drug Indication":"Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.","Drug Warnings":"Known hypersensitivity to pregabalin or any ingredient in the formulation.","DurationOfAction":"8 – 12 hours \u003ca href='#cite_note-6'\u003e\u003csup\u003e[6]\u003c/sup\u003e\u003c/a\u003e","EliminationHalfLife":"4.5 – 7 hours\u003ca href='#cite_note-4'\u003e\u003csup\u003e[4]\u003c/sup\u003e\u003c/a\u003e (mean 6.3 hours)\u003ca href='#cite_note-5'\u003e\u003csup\u003e[5]\u003c/sup\u003e\u003c/a\u003e","Erowid Experience Reports":[{"Author":"sugarcube","Id":47687,"Title":"Here I Go Again!"},{"Author":"Edmund","Id":66842,"Title":"The Mood Lift"},{"Author":"Half-Pipe","Id":68488,"Title":"Streams of Color and Haze"},{"Author":"Mickey","Id":85040,"Title":"A New Kind of High"},{"Author":"R9T3","Id":106972,"Title":"Closed Eye Visuals Similar to Lucid Dreaming"},{"Author":"Greg!","Id":83033,"Title":"Helps with Withdrawal"},{"Author":"Clear Skies","Id":53871,"Title":"Like Doing Multivariable Calculus"},{"Author":"Absinthe750mL","Id":53791,"Title":"Amazingly Spiritual"},{"Author":"justpassinthru","Id":102340,"Title":"Weird Attypical Non-Response"},{"Author":"Horatio","Id":94419,"Title":"Is It Really Euphoric"},{"Author":"johnweythekylow","Id":94903,"Title":"Next Step"},{"Author":"GummiiBear","Id":95156,"Title":"Everything Is Familiar"},{"Author":"TheFeast","Id":95952,"Title":"How Is This Not CII?"},{"Author":"Curious","Id":96309,"Title":"The Perfect Mood"},{"Author":"AnCapKevin","Id":96542,"Title":"The Euphoria Hooked Me"},{"Author":"BadmanBernarde","Id":102907,"Title":"A Better Night In"},{"Author":"HIVpozbear","Id":101841,"Title":"Amazing Time Slip"},{"Author":"Courtnee","Id":98004,"Title":"Are You Kidding Me"},{"Author":"Shaggy Rogers","Id":93138,"Title":"Drunken Euphoria"},{"Author":"lizzard king","Id":91551,"Title":"Best High Ever"},{"Author":"SomeGirl","Id":82468,"Title":"Ambivalent About the High"},{"Author":"lynzi","Id":82656,"Title":"Got Rid of Fibro and Myofascial Pain"},{"Author":"TheMacGrizzy","Id":83121,"Title":"Pregabalin vs Gabapentin"},{"Author":"Frenchman","Id":83959,"Title":"An Expensive High..."},{"Author":"the other one","Id":86033,"Title":"Positive Pregabalin Retrospective"},{"Author":"Philip T","Id":86585,"Title":"Fantastic Falling"}],"Esters":[],"European Community (EC) Number":"604-639-1","Formating":[],"HMDB ID":"HMDB0014375","HeavyAtomCount":11,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Analgesics; Anticonvulsants","IUPACName":"(3S)-3-(aminomethyl)-5-methylhexanoic acid","InChI":"InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1","InChIKey":"AYXYPKUFHZROOJ-ZETCQYMHSA-N","Interactions":"Patients who require concomitant treatment with central nervous system depressants such as opiates or benzodiazepines should be informed that they may experience additive CNS side effects, such as somnolence.","MeSH Headers":[{"Id":"M0214473","Link":"https://id.nlm.nih.gov/mesh/M0214473.html","Name":"Pregabalin","Ref":117},{"Id":"M0259583","Link":"https://id.nlm.nih.gov/mesh/M0259583.html","Name":"CI 1008","Ref":119},{"Id":"M0486135","Link":"https://id.nlm.nih.gov/mesh/M0486135.html","Name":"Lyrica","Ref":120},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":121},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":149},{"Id":"M0001067","Link":"https://id.nlm.nih.gov/mesh/M0001067.html","Name":"Analgesics","Ref":150},{"Id":"M0001382","Link":"https://id.nlm.nih.gov/mesh/M0001382.html","Name":"Anticonvulsants","Ref":151},{"Id":"M0003165","Link":"https://id.nlm.nih.gov/mesh/M0003165.html","Name":"Calcium Channel Blockers","Ref":152},{"Id":"M0021771","Link":"https://id.nlm.nih.gov/mesh/M0021771.html","Name":"Anti-Anxiety Agents","Ref":153}],"MeSH Pharmacological Classification":[{"Id":"M0001067","Link":"https://id.nlm.nih.gov/mesh/M0001067.html","Name":"Analgesic","Ref":150},{"Id":"M0001382","Link":"https://id.nlm.nih.gov/mesh/M0001382.html","Name":"Anticonvulsant","Ref":151},{"Id":"M0003165","Link":"https://id.nlm.nih.gov/mesh/M0003165.html","Name":"Calcium Channel Blocker","Ref":152},{"Id":"M0021771","Link":"https://id.nlm.nih.gov/mesh/M0021771.html","Name":"Anti-Anxiety Agent","Ref":153}],"Mechanism of Action":"Although the mechanism of action has not been fully elucidated, studies involving structurally related drugs suggest that presynaptic binding of pregabalin to voltage-gated calcium channels is key to the antiseizure and antinociceptive effects observed in animal models.    By binding presynaptically to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, pregabalin modulates the release of several excitatory neurotransmitters including glutamate, substance-P, norepinephrine, and calcitonin gene related peptide. In addition, pregabalin prevents the alpha2-delta subunit from being trafficked from the dorsal root ganglia to the spinal dorsal horn, which may also contribute to the mechanism of action.   Although pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors.","Melting Point":"186-188 °C","Metabolism/Metabolites":"Less than 2% of pregabalin is metabolized and it is excreted virtually unchanged in the urine.","MolecularFormula":"C\u003csub\u003e8\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"159.23 g/mol","Opticalactivity":"( + )","PD":"PD-144723","Pharmacodynamics":"Although the structure of pregabalin is similar to gamma-aminobutyric acid (GABA), it does not bind to GABA receptors. Instead, it binds the alpha2-delta subunit of presynaptic voltage-gated calcium channels in the central nervous system. Pregabalin does not modulate dopamine receptors, serotonin receptors, opiate receptors, sodium channels or cyclooxygenase activity.","Physical Description":"Solid","PubChemId":5486971,"PubChemTitle":"Pregabalin","Reagents":[{"Colors":[],"Name":"Marquis"},{"Colors":[],"Name":"Mecke"},{"Colors":[],"Name":"Mandelin"},{"Colors":[],"Name":"Liebermann"},{"Colors":[],"Name":"Froehde"},{"Colors":["#fde9d9","#ff6fcf"],"Name":"Robadope"},{"Colors":["#fde9d9","#50268d"],"Name":"Simon's"},{"Colors":[],"Name":"Ehrlich"},{"Colors":[],"Name":"Hofmann"},{"Colors":["#ff6fcf","#7aefa6"],"Name":"Morris"},{"Colors":["#ffffff","#ffffff","#ffffcc"],"Name":"Zimmermann"}],"Record Description":["LiverTox|CNS|Anticonvulsant|GABA analogue"],"Records":{"UNII":{"Impurities":["pregabalin lactam, (±)-","3-(2-amino-2-oxoethyl)-5-methylhexanoic acid, (3r)-","isobutylglutaric acid","pregabalin, (r)-",".alpha.-d-tagatopyranose, 1-deoxy-1-((4s)-4-(2-methylpropyl)-2-oxo-1-pyrrolidinyl)-","(z)-2-cyano-5-methylhex-2-enamide","3-isobutylpyrrolidine-2,5-dione","2,4-dicyano-3-isobutylpentanediamide","(s)-3-(aminomethyl)-n,n-diethyl-5-methylhexanamide"]}},"RefChem":"6163","RefCount":7,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Pregabalin","Name":"Pregabalin","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00230","Name":"Pregabalin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5486971","Name":"Pregabalin","Sub":false}]},{"Name":"Probes \u0026 Drugs","Urls":[{"Link":"https://www.probes-drugs.org/compound/PD-144723","Name":"Pregabalin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=148553-50-8","Name":"Pregabalin","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014375","Name":"Pregabalin","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D02716","Name":"Pregabalin","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/55JG375S6M","Name":"Pregabalin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1045950","Name":"Pregabalin","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5486971, Pregabalin. Accessed May 30, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5486971\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5486971\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pregabalin. UNII: 55JG375S6M. Global Substance Registration System. Accessed May 30, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/55JG375S6M\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/55JG375S6M\u003c/a\u003e","Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. June 21, 2022. Accessed May 30, 2026. \u003ca href=https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017\u003ehttps://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017\u003c/a\u003e","Expert Committee on Drug Dependence Forty-first Meeting. Critical Review Report: Pregabalin. World Health Organization. November 1, 2018. Accessed May 30, 2026. \u003ca href=https://www.who.int/medicines/access/controlled-substances/Pregabalin_FINAL.pdf?ua=1\u003ehttps://www.who.int/medicines/access/controlled-substances/Pregabalin_FINAL.pdf?ua=1\u003c/a\u003e","Cross AL, Viswanath O, Sherman AI. StatPearls [Internet]. StatPearls Publishing. July 19, 2022. Accessed May 30, 2026. \u003ca href=https://www.ncbi.nlm.nih.gov/books/NBK470341/\u003ehttps://www.ncbi.nlm.nih.gov/books/NBK470341/\u003c/a\u003e","BNF Pregabalin. NICE. November 16, 2018. 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