N-Cyclohexylmethylone

Cyputylone

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	275.34 g/mol ^[1]
Predicted LogP	3.2 ^[1]

Structural Identifiers []
Molecular formula	C₁₆H₂₁NO₃ ^[1]
IUPAC name	1-(1,3-benzodioxol-5-yl)-2-(cyclohexylamino)propan-1-one ^[1]
SMILES	CC(C(=O)C1=CC2=C(C=C1)OCO2)NC3CCCCC3 ^[1]
InChI	InChI=1S/C16H21NO3/c1-11(17-13-5-3-2-4-6-13)16(18)12-7-8-14-15(9-12)20-10-19-14/h7-9,11,13,17H,2-6,10H2,1H3 ^[1]
InChIKey	WZDQUORQDHVTKD-UHFFFAOYSA-N ^[1]

N-Cyclohexylmethylone (also known as Cybutylone, 3,4-Methylenedioxy-?-Cyclohexylaminopropiophenone, 1-(1,3-Benzodioxol-5-yl)-2-(cyclohexylamino)propan-1-one, 1-(benzo-1,3-dioxol-5-yl)-2-(cyclohexylamino)propan-1-one or 1-(Benzo[d][1,3]dioxol-5-yl)-2-(cyclohexylamino)propan-1-one) is a stimulant substance of the 3,4-methylenedioxyphenethylamine and cathinone class.

Chemistry

Stereochemistry []

N-Cyclohexylmethylone is a racemic mixture of the enantiomers.

Stereoisomerism
(R)-N-Cyclohexylmethylone (S)-N-Cyclohexylmethylone
Stereoisomer enumberation with rdkit

Subjective effects []

class / Stimulant

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Legal status []

United Kingdom: N-Cyclohexylmethylone is a Class B substance.
Germany: N-Cyclohexylmethylone is a Anlage II substance.
United States: N-Cyclohexylmethylone is a Unscheduled, schedule I in Virginia substance.^[2]

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 164946391, N-Cyclohexylmethylone. Accessed October 14, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/164946391
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. N-Cyclohexylmethylone. UNII: AB5UNF3WUF. Global Substance Registration System. Accessed October 14, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/AB5UNF3WUF
§ 54.1-3446. Schedule I.. Accessed October 14, 2026. https://law.lis.virginia.gov/vacode/title54.1/chapter34/section54.1-3446/

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