Codeine

Codeine

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	299.4 g/mol ^[1]
Density	1.32 at 68 °F (NTP, 1992) - Denser than water; will sink g/cm³ ^[1]
Appearance	Orthorhombic crystals from water, dilute alcohol, ether ^[1]
Melting point	309 to 313 °F (after drying at 176 °F) (NTP, 1992) ^[1]
Boiling point	482 ° ^[1]
Decomposition	When heated to decomposition it emits toxic fumes of /nitrogen oxides/. ^[1]
Solubility	less than 1 mg/mL at 70 °F (NTP, 1992) ^[1]
Predicted LogP	1.1 ^[1]

Structural Identifiers []
Molecular formula	C₁₈H₂₁NO₃ ^[1]
IUPAC name	(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol ^[1]
SMILES	CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O ^[1]
InChI	InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1 ^[1]
InChIKey	OROGSEYTTFOCAN-DNJOTXNNSA-N ^[1]

Codeine (also known as Methylmorphine, Codeine anhydrous, Codicept, Coducept, Morphine monomethyl ether, O3-Methylmorphine, Morphine 3-methyl ether, codeinum, Codeine base or Morphine-3-methyl ether) is a prodrug and opioid substance of the morphinan class.

Chemistry

Pharmacology

ATC Classification

Metabolism

Metabolic pathways []
> Codeine Morphine Codeine-6-glucuronide

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

Mere / Codeine []

emily / Codeine []
Routes: Oral (12.8 - 140mg)

michalina / Codeine []
Effects: light sedation little euphoria stomach pain Notes: lean or pills from pharmacy (1 package codeine per individual is allowed, sometimes pharmacist verifies age, because de facto codeine like dxm in Poland is controlled OTC substance for adults only +18)

michalina / Codeine []

Effects:

light sedation
little euphoria
stomach pain

Notes:

lean or pills from pharmacy (1 package codeine per individual is allowed, sometimes pharmacist verifies age, because de facto codeine like dxm in Poland is controlled OTC substance for adults only +18)

Pilz / Codeine []
Routes: Oral (12.8 - 140mg) Salts: Phosphate Source: Polish Pharmacy: Nurofen plus tablets Effects: strong pain relief moderate cognitive euphoria light sedation light thought deceleration in high doses (140mg+)

Pilz / Codeine []

Routes:

Oral (12.8 - 140mg)

Salts:

Phosphate

Source:

Polish Pharmacy: Nurofen plus tablets

Effects:

strong pain relief
moderate cognitive euphoria
light sedation
light thought deceleration in high doses (140mg+)

magnus / Codeine []
Routes: Oral

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 5284371, Codeine. Accessed July 19, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5284371
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Codeine. UNII: UX6OWY2V7J. Global Substance Registration System. Accessed July 19, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/UX6OWY2V7J

AnodyneWiki

Codeine

Chemistry

Stereochemistry []

Pharmacology

ATC Classification

Metabolism

Subjective effects []

See also []

External links []

References []