Anodyne| Buprenorphine | |
|---|---|
 | |
| Esters [] | |
|---|---|
| Buprenorphine palmitate | |
|
| Molecular structure via molpic based on CDK |
| Conformer [] | |
|---|---|
| Conformer structure via JSmol | |
| Physical properties [] | |
|---|---|
| Molecular mass | 467.6 g/mol [1] |
| Solubility | 1.68e-02 g/L [1] |
| Predicted LogP | 5 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C29H41NO4 [1] |
| IUPAC name | (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol [1] |
| SMILES | C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)(C(C)(C)C)O [1] |
| InChI | InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1 [1] |
| InChIKey | RMRJXGBAOAMLHD-IHFGGWKQSA-N [1] |
| Dosing [] | |
|---|---|
| Elimination half-life | 37 hours (range 20 – 70 hours) |
| Duration of action | 24 hours |
Buprenorphine
Buprenorphine (also known as Temgesic, Buprenophine, Buprenorfina, Buprenorphinum, Butrans, buprenorphin, Probuphenine, Brixadi, Buvidal or CAM2038) is a opioid substance of the morphinan class.
Chemistry
Salts and Esters []
Buprenorphine is typically found in the form of its hydrochloride salt
or its ester.
Stereochemistry []
Buprenorphine is a absolute mixture
Subjective effects
Experience reports []
There are currently 25+ experience reports involving buprenorphine on OpenErowid:
- "Should Have Stayed the Course" by bupedupe
- "I Ended Up Depressed Over Where I Was At" by Jay0815
- "Love It Though" by OnImpulse
- "The Lifeline" by Over-Easy
- "Never Felt So Nauseous Before in My Life" by MMTS
- "The Orange Pledge Flavor in My Mouth" by Jeffy
- "No Euphoria, Just Fairground Sickness" by magicroundabout
- "Overlooked Taper Method" by MaskedJackalope
- "An Opioid That Allows Me to Function" by Eric
- "Buprenorphine: Itchy, sleepy, and addictive" by Stranger
- "Saved My Life" by James
- "Some Facts" by providedFor
- "Kinder Gentler Opiate" by Rahjen Black
- "A Legal Addiction" by Moon
- "Lasted Four to Six Hours" by Becky
- "Withdrawals Are Hell, or Worst" by Sc0rp
- "Not What I Expected" by firefaery
- "Wow, Strong" by spaceman
- "Interrupted" by BB
- "Is This What Normal Is?" by Wilykit11001
- "A Drug of Choice" by Hemoglobin
- "Paranoia, Anxiety and Disjointed Thoughts" by philbert
- "Please Don't Take It All" by mr jingles
- "I Wanted to Go on Maintenance" by Liamfinnegan
- "Sublingual Handcuffs" by brdrline
Legal status
- Australia: Buprenorphine is a S8 substance.
- Brazil: Buprenorphine is a A1 substance.[3]
- Canada: Buprenorphine is a Schedule I substance.
- Germany: Buprenorphine is a Anlage III substance.
- United Kingdom: Buprenorphine is a Class C substance.
- United States: Buprenorphine is a Schedule I under the "Controlled Substances Act (CSA)".
- European Union: Buprenorphine is a prescription only substance.
- United Nations: Buprenorphine is a Schedule III drug under the "Convention on Psychotropic Substances 1971".
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 644073, Buprenorphine. Accessed June 26, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/644073
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Buprenorphine. UNII: 40D3SCR4GZ. Global Substance Registration System. Accessed June 26, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/40D3SCR4GZ
Anvisa. RDC Nº 784 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed June 26, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992