Anodyne

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2-Cl-2'-Oxo-PCM, K
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
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Ketamine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
Conformer structure via 3Dmol.js
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Physical properties
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237.72 g/mol [1]
AppearanceCrystals from pentane-ether [1]
Melting point92.5ºC [1]
DecompositionWhen heated to decomposition it emits toxic fumes of /chloride/ and /nitrogen oxides/. [1]
SolubilitySoluble [1]
2.2 [1]
Structural Identifiers
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C13H16ClNO [1]
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one [1]
CNC1(CCCCC1=O)C2=CC=CC=C2Cl [1]
InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 [1]
InChIKeyYQEZLKZALYSWHR-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life* Ketamine: 2.5 – 3 hours * Norketamine: 12 hours
Duration of action* Intramuscular: 0.5 – 2 hours * Insufflation: 45 – 60 min * By mouth: 1 – 6+ hours
Toxicity
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Mouse:
- intravenous: 77 mg/kg
- intraperitoneal: 400 mg/kg

Ketamine

Ketamine (also known as Ketamine, ketamine, Ketaject, Special K, CI 581 base, Ketaminum, CLSTA 20, Calypsol, narketan or Cetamina) is a substance of the arylcyclohexylamine class.

Chemistry

Salts []

Ketamine is typically found in the form of its hydrochloride salt.

 []

Ketamine is a racemic mixture of the

Stereoisomers
EsketamineGenerated by the Chemistry Development Kit (http://github.com/cdk)
EsketamineGenerated by the Chemistry Development Kit (http://github.com/cdk)
Anodyne Usernotes
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magnus / Ketamine[hydrochloride] via Insufflated
    -
0xea / Ketamine[hydrochloride] via Insufflated and Intravenous at 50-100mg insufflated and 10-30mg intravenous

Legal status []

  • Australia: Ketamine is a S8 substance.
  • Brazil: Ketamine is a C1 substance.
  • Canada: Ketamine is a Schedule I substance.
  • Germany: Ketamine is a prescription only substance.
  • United Kingdom: Ketamine is a Class B (Class A if prepared as an injection) substance.
  • United States: Ketamine is a Schedule I under the "Controlled Substances Act (CSA)".
  • United Nations: Ketamine is a Unscheduled substance.

See also []

  • Substituted arylcyclohexylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 3821, Ketamine. Accessed September 6, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/3821

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Ketamine. UNII: 690G0D6V8H. Global Substance Registration System. Accessed September 6, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/690G0D6V8H