Fentanyl

Fentanyl

Salts []
Fentanyl citrate

Fentanyl hydrochloride

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	336.5 g/mol ^[1]
Appearance	Crystals ^[1]
Melting point	83-84 ^[1]
Decomposition	When heated to decomposition it emits toxic fumes of /nitrogen oxides/. ^[1]
Solubility	0.74mg/mL ^[1]
Predicted LogP	4 ^[1]

Structural Identifiers []
Molecular formula	C₂₂H₂₈N₂O ^[1]
IUPAC name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ^[1]
SMILES	CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3 ^[1]
InChI	InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3 ^[1]
InChIKey	PJMPHNIQZUBGLI-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	Intravaneous: 6 mins (T_1/2 α) 1 hours (T_1/2 β) 16 hours (T_1/2 ɣ)Intranasal: 15 – 25 hoursTransdermal: 20 – 27 hoursSublingual: 5 – 13.5 hoursBuccal: 3.2 – 6.4 hours
Duration of action	Intravaneous: 30 – 60 minutes^[5]

Fentanyl (also known as Phentanyl, Fentanil, Fentanest, Duragesic, Sublimase, Fentanylum, Durogesic, Fentanila, Matrifen or Duragesic-100) is a opioid substance of the phenethylpiperidine class.

Chemistry

Salts []

Fentanyl is typically found in the form of its citrate and hydrochloride salts.

Stereochemistry []

Fentanyl is a achiral mixture.

Reagents

There are currently 3 reagent-interactions on DrugsPRO

Reagent	Color change
Marquis
Mecke
Mandelin

Pharmacology

ATC Classification

In the nervous system (N) fentanyl acts In the nervous system (N) fentanyl acts as a analgesic (N02), anesthetic (N01), anesthetics, general (N01A), fentanyl (N01AH01), fentanyl (N02AB03), opioid anesthetic (N01AH), opioid (N02A) and phenylpiperidine derivative (N02AB).^[1]

Interactions []

CYP3A4	induction / inhibition

Subjective effects []

class / Opioid

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

bonzi / Fentanyl []

0xea / Fentanyl []
Routes: Intravenous (15 - 375mcg) Onset: 5 - 10 s Comeup: 30 s Duration: 60 - 120 m Subcutaneous (50 - 250mcg) Onset: 7 - 8 m Comeup: 10 m Duration: 60 - 120 m Vaporized (250 - 1000mcg) Onset: 5 - 10 s Comeup: 30 s Duration: ? Salts: D-Tartrate Citrate Source: Fentanyl: DNM Germany Indication: pain anxiety panick attack fear of abandonment Effects: moderate wakefulness (causes only temporary non-restful loss of conciousness for only about an hour of time.once conciousness is regained onsumption is typically resumed) strong anxiety suppression moderate cognitive euphoria strong pain relief disinhibition moderate analysis suppression perception of bodily heaviness moderate thought deceleration moderate tinnitus muscle relaxation pupil constriction reverse moderate increased music appreciation strong compulsive redosing addiction suppression (helps discontinue nicotine addiction at the cost of fentanyl addiction) doesn't help while experiencing a bad trip Intravenous 25mcg increased bodily temperature increased perspiration auditory suppression moderate motivation enhancement (weirdly helps with productivity and tedious physical work) dizziness strong motor control loss (struggle to type correctly) Intravenous 50mcg intense double vision strong nausea strong vomiting strong sedation (often resulting in loss of conciousness) After Effects: constipation moderate motor control loss (1-2 days) muscle tension pain sensitization Notes: intravenously using volumetric liquid dosing only. eyeballing or measuring out single injections would likely be deadly. intravenous injection of unsanitary solution repeatedly lead to the development of soars all around my body(unrelated to venipuncture)

0xea / Fentanyl []

Routes:

Intravenous (15 - 375mcg)
Onset: 5 - 10 s
Comeup: 30 s
Duration: 60 - 120 m
Subcutaneous (50 - 250mcg)
Onset: 7 - 8 m
Comeup: 10 m
Duration: 60 - 120 m
Vaporized (250 - 1000mcg)
Onset: 5 - 10 s
Comeup: 30 s
Duration: ?

Salts:

D-Tartrate
Citrate

Source:

Fentanyl: DNM Germany

Indication:

pain
anxiety
panick attack
fear of abandonment

Effects:

moderate wakefulness (causes only temporary non-restful loss of conciousness for only about an hour of time.once conciousness is regained onsumption is typically resumed)
strong anxiety suppression
moderate cognitive euphoria
strong pain relief
disinhibition
moderate analysis suppression
perception of bodily heaviness
moderate thought deceleration
moderate tinnitus
muscle relaxation
pupil constriction
reverse moderate increased music appreciation
strong compulsive redosing
addiction suppression (helps discontinue nicotine addiction at the cost of fentanyl addiction)
doesn't help while experiencing a bad trip

Intravenous 25mcg

increased bodily temperature
increased perspiration
auditory suppression
moderate motivation enhancement (weirdly helps with productivity and tedious physical work)
dizziness
strong motor control loss (struggle to type correctly)

Intravenous 50mcg

intense double vision
strong nausea
strong vomiting
strong sedation (often resulting in loss of conciousness)

After Effects:

constipation
moderate motor control loss (1-2 days)
muscle tension
pain sensitization

Notes:

intravenously using volumetric liquid dosing only. eyeballing or measuring out single injections would likely be deadly.
intravenous injection of unsanitary solution repeatedly lead to the development of soars all around my body(unrelated to venipuncture)

Experience reports

Erowid

There are currently 26 experience reports involving fentanyl on Erowid: []

Legal status []

Australia: Fentanyl is a S8 substance.
Brazil: Fentanyl is a Class A1 substance.
Canada: Fentanyl is a Schedule I substance.
Germany: Fentanyl is a Anlage III substance.
New Zealand: Fentanyl is a Class B substance.
United Kingdom: Fentanyl is a Class A substance.
United States: Fentanyl is a Controlled Substances Act#Schedule II|Schedule II substance.
European Union: Fentanyl is a prescription only substance.^[3]^[4]
United Nations: Fentanyl is a Schedule I narcotic under the "Single Convention on Narcotic Drugs 1961".

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 3345, Fentanyl. Accessed May 24, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3345
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Fentanyl. UNII: UF599785JZ. Global Substance Registration System. Accessed May 24, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/UF599785JZ
Instanyl EPAR. July 20, 2009. Accessed May 24, 2026. https://www.ema.europa.eu/en/medicines/human/EPAR/instanyl
Effentora EPAR. April 4, 2008. Accessed May 24, 2026. https://www.ema.europa.eu/en/medicines/human/EPAR/effentora
Guideline for administration of fentanyl for pain relief in labour. RCP. Accessed May 24, 2026. http://rcp.nshealth.ca/sites/default/files/clinical-practice-guidelines/fentanyl.pdf

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