Methamphetamine

Salts []
Methamphetamine hydrochloride

Physical properties []
Molecular mass	149.23 g/mol ^[1]
Predicted LogP	2.1 ^[1]

Structural Identifiers []
Molecular formula	C₁₀H₁₅N ^[1]
IUPAC name	N-methyl-1-phenylpropan-2-amine ^[1]
SMILES	CC(CC1=CC=CC=C1)NC ^[1]
InChI	InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3 ^[1]
InChIKey	MYWUZJCMWCOHBA-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	9 – 12 hours (range 5 – 30 hours); irrespective of route
Duration of action	8 – 12 hours^[4]

Insufflated []
Light	≤ 15 mg(34x - 41.5%)
Common	15 - 20 mg(13x - 15.9%)
Strong	20 - 27.3 mg(14x - 17.1%)
Heavy	27.3 - 31.8 mg(12x - 14.6%)
Extreme	31.8 mg +(9x - 11%)

Intravenous []
Light	≤ 56.2 mg(30x - 47.6%)
Common	56.2 - 130 mg(2x - 3.2%)
Strong	130 - 180 mg(22x - 34.9%)
Heavy	180 - 200 mg(6x - 9.5%)
Extreme	200 mg +(3x - 4.8%)

Oral []
Light	≤ 20 mg(5x - 83.3%)
Common	20 mg
Strong	20 mg
Heavy	20 - 22 mg
Extreme	22 mg +(1x - 16.7%)

Intrarectal []
Light	≤ 51.2 mg(4x - 57.1%)
Common	51.2 mg
Strong	40 - 200 mg(1x - 14.3%)
Heavy	200 - 300 mg(2x - 28.6%)
Extreme	300 mg +

Vaporized []
Light	≤ 11.1 mg(12x - 57.1%)
Common	11.1 mg
Strong	10 - 25 mg(4x - 19%)
Heavy	25 - 50 mg(4x - 19%)
Extreme	50 mg +(1x - 4.8%)

Methamphetamine (also known as Pervertin, Anadrex, (2-Methylaminopropyl)benzene, N,α-Dimethylbenzeneethanamine, Benzeneethanamine, N,α-dimethyl-, N-Methyl-1-phenyl-2-propylamine, α-Phenyl-β-methylaminopropane, Einecs 231-559-0, Phenethylamine, N,α-dimethyl- or NSC-403767) is a stimulant substance of the amphetamine class.

Chemistry

Salts []

Methamphetamine is typically found in the form of its hydrochloride salt.

Stereochemistry []

Methamphetamine is a racemic mixture of the enantiomers.

Stereoisomerism
Levomethamphetamine Dextromethamphetamine
Stereoisomer enumberation with rdkit

Reagents

There are currently 12 reagent-interactions on DrugsPRO

Reagent	Color change
Marquis
Mecke
Mandelin
Liebermann
Froehde
Robadope
Simon's
Ehrlich
Hofmann
Scott
Morris
Folin

Subjective effects []

class / Stimulant

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Mere / Methamphetamine []

bonzi / Methamphetamine []
Routes: Oral (25mg)

x86pup / Methamphetamine []
Routes: Oral

0xea / Methamphetamine []
Routes: Oral (10 - 50mg) Onset: ~ 35 m Duration: ~ 6 - 8 h Insufflated (10 - 20mg) Intrarectal (5 - 20mg) Subcutaneous (4.2 - 15mg) Intramuscular (10 - 15mg) Onset: 30 - 60 s Duration: ? Intravenous (10 - 60mg) Onset: 10 - 15 s Duration: 1 - 8 h Vaporized Salts: Hydrochloride Source: Crystal Meth (Ephedrine): DNM Germany Crystal Meth: Goerlitzer park Indication: motivation suppression (executive dysfunction) depression sleepiness cognitive dysphoria Effects: strong stimulation without tolerance short-acting intense cognitive euphoria intense focus enhancement (often resulting in a state of day long hyper-focus which may or may not be counter-productive) strong wakefulness (up to 6+ days) strong motivation enhancement strong stamina enhancement strong dry mouth appetite suppression (often resulting in malnutrition long-term) thirst suppression strong compulsive redosing increased libido without tolerance strong depression reduction acute relief of constipation strong headache suppression strong addiction (+10g consumed; compulsive drug seeking on the street; psychological breakdown; intense mental dulling and tolerance) headache psychosis shadow people (friendly shadow person doing code-review) time compression (perception of music and other human beings comically speed up) autonomous entity (hallucination of a man sitting in a chair next to me taunting me; pieces of dust manifesting as hallucinations of spider like creatures) lights shine through my courtains rain coming from the sealing auditory hallucination (phantom music playing as if I were wearing headphones) autonomous voice communication (voices of my mother and father screaming at each other for hours about my drug habit; mocking and laughter; police officer screaming in stair-way all night; police radio chatter blaring through the street spelling my name; hallucinations of my partner making fun of me to her friends and threatening to seriously hurt me) delusion (cotard's syndrome) After Effects: wakefulness (for another 24 hours) feelings of impending doom (for 1-5 days) panic attack (for 1-5 days) depression motivation suppression (for 1-2 weeks)

0xea / Methamphetamine []

Routes:

Oral (10 - 50mg)
Onset: ~ 35 m
Duration: ~ 6 - 8 h
Insufflated (10 - 20mg)
Intrarectal (5 - 20mg)
Subcutaneous (4.2 - 15mg)
Intramuscular (10 - 15mg)
Onset: 30 - 60 s
Duration: ?
Intravenous (10 - 60mg)
Onset: 10 - 15 s
Duration: 1 - 8 h
Vaporized

Salts:

Hydrochloride

Source:

Crystal Meth (Ephedrine): DNM Germany
Crystal Meth: Goerlitzer park

Indication:

motivation suppression (executive dysfunction)
depression
sleepiness
cognitive dysphoria

Effects:

strong stimulation
without tolerance short-acting intense cognitive euphoria
intense focus enhancement (often resulting in a state of day long hyper-focus which may or may not be counter-productive)
strong wakefulness (up to 6+ days)
strong motivation enhancement
strong stamina enhancement
strong dry mouth
appetite suppression (often resulting in malnutrition long-term)
thirst suppression
strong compulsive redosing
increased libido
without tolerance strong depression reduction
acute relief of constipation
strong headache suppression
strong addiction (+10g consumed; compulsive drug seeking on the street; psychological breakdown; intense mental dulling and tolerance)
headache
psychosis
shadow people (friendly shadow person doing code-review)
time compression (perception of music and other human beings comically speed up)
autonomous entity (hallucination of a man sitting in a chair next to me taunting me; pieces of dust manifesting as hallucinations of spider like creatures)
lights shine through my courtains
rain coming from the sealing
auditory hallucination (phantom music playing as if I were wearing headphones)
autonomous voice communication (voices of my mother and father screaming at each other for hours about my drug habit; mocking and laughter; police officer screaming in stair-way all night; police radio chatter blaring through the street spelling my name; hallucinations of my partner making fun of me to her friends and threatening to seriously hurt me)
delusion (cotard's syndrome)

After Effects:

wakefulness (for another 24 hours)
feelings of impending doom (for 1-5 days)
panic attack (for 1-5 days)
depression
motivation suppression (for 1-2 weeks)

Experience reports

Erowid

There are currently 586 experience reports involving methamphetamine on Erowid: []

There are currently 214 trip reports involving methamphetamine on Reddit: []

Legal status []

Australia: Methamphetamine is a S8 substance.
Brazil: Methamphetamine is a F2 substance.^[3]
Canada: Methamphetamine is a Schedule I substance.
Germany: Methamphetamine is a Anlage II substance.
New Zealand: Methamphetamine is a Class A substance.
United Kingdom: Methamphetamine is a Class A substance.
United States: Methamphetamine is a Schedule I under the "Controlled Substances Act (CSA)".
European Union: Methamphetamine is a prescription only substance.
United Nations: Methamphetamine is a Schedule II substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 1206, Methamphetamine. Accessed June 9, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/1206
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Methamphetamine. UNII: 13ZT6YG5SD. Global Substance Registration System. Accessed June 9, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/13ZT6YG5SD
Anvisa. RDC Nº 804 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. July 24, 2023. Accessed June 9, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451
Courtney KE, Ray LA. Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend. October 1, 2014; 143():11–21.

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