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Fluoxetine

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Fluoxetine
Fluoxetine
Salts
[]
Fluoxetine oxalate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Fluoxetine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
309.33 g/mol [1]
Melting point179 - 182 °C [1]
Boiling point395.1°C at 760 mmHg [1]
Solubilityinsoluble [1]
4 [1]
Structural Identifiers
[]
C17H18F3NO [1]
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine [1]
CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F [1]
InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 [1]
InChIKeyRTHCYVBBDHJXIQ-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life1 – 3 days (acute)4 – 6 days (chronic)

Fluoxetine (also known as Fluoxetine, Fluoxetina, Animex-On, Fluval, Fluoxetinum, Fluoxetin, N-Methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine, N-Methyl-3-phenyl-3-((α,α,α-trifluoro-p-tolyl)oxy)propylamine, Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine or Dtxsid7023067) is a serotonin reuptake inhibitor substance of the phenylpropylamine class.

Chemistry

Salts []

Fluoxetine is typically found in the form of its oxalate and hydrochloride salts.

 []

Fluoxetine is a racemic mixture of the .

(R)-FluoxetineGenerated by the Chemistry Development Kit (http://github.com/cdk)
(S)-FluoxetineGenerated by the Chemistry Development Kit (http://github.com/cdk)
Stereoisomer enumberation with rdkit

Pharmacology

In the () fluoxetine acts as a antidepressant (), fluoxetine (), psychoanaleptic () and selective serotonin reuptake inhibitor ().[1]

Metabolism

Interactions []

CYP2D6induction / inhibition
CYP2C9induction / inhibition
CYP2C19inhibition
CYP3Ainhibition

Subjective effects []

bonzi / Fluoxetine []
0xea / Fluoxetine []
Routes:
  • Oral
Salts:
  • Hydrochloride
Indication:Active Effects:

Legal status []

  • Australia: Fluoxetine is a S4 substance.[3]
  • Brazil: Fluoxetine is a C1 substance.
  • Canada: Fluoxetine is a prescription only substance.
  • United Kingdom: Fluoxetine is a prescription only substance.
  • United States: Fluoxetine is a prescription only substance.
  • European Union: Fluoxetine is a prescription only substance.

See also []

  • Substituted phenylpropylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 3386, Fluoxetine. Accessed April 15, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3386

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Fluoxetine. UNII: 01K63SUP8D. Global Substance Registration System. Accessed April 15, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/01K63SUP8D

    3. Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. June 21, 2022. Accessed April 15, 2026. https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017