Fluoxetine

Fluoxetine

Salts []
Fluoxetine oxalate

Fluoxetine hydrochloride

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	309.33 g/mol ^[1]
Melting point	179 - 182 °C ^[1]
Boiling point	395.1°C at 760 mmHg ^[1]
Solubility	insoluble ^[1]
Predicted LogP	4 ^[1]

Structural Identifiers []
Molecular formula	C₁₇H₁₈F₃NO ^[1]
IUPAC name	N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine ^[1]
SMILES	CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F ^[1]
InChI	InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 ^[1]
InChIKey	RTHCYVBBDHJXIQ-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	1 – 3 days (acute)4 – 6 days (chronic)

Fluoxetine (also known as Fluoxetine, Fluoxetina, Animex-On, Fluval, Fluoxetinum, Fluoxetin, N-Methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine, N-Methyl-3-phenyl-3-((α,α,α-trifluoro-p-tolyl)oxy)propylamine, Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine or Dtxsid7023067) is a serotonin reuptake inhibitor substance of the phenylpropylamine class.

Chemistry

Salts []

Fluoxetine is typically found in the form of its oxalate and hydrochloride salts.

Stereochemistry []

Fluoxetine is a racemic mixture of the enantiomers.

Stereoisomerism
(R)-Fluoxetine (S)-Fluoxetine
Stereoisomer enumberation with rdkit

Pharmacology

ATC Classification

In the nervous system (N) fluoxetine acts as a antidepressant (N06A), fluoxetine (N06AB03), psychoanaleptic (N06) and selective serotonin reuptake inhibitor (N06AB).^[1]

Metabolism

Interactions []

CYP2D6	induction / inhibition
CYP2C9	induction / inhibition
CYP2C19	inhibition
CYP3A	inhibition

Subjective effects []

bonzi / Fluoxetine []

0xea / Fluoxetine []
Routes: Oral Salts: Hydrochloride Indication: depression Active Effects: light depression reduction (acute effects; long term no notable improvement in quality of life) light potenciation of dextroamphetamine through CYP2D6 inhibition

0xea / Fluoxetine []

Routes:

Oral

Salts:

Hydrochloride

Indication:

depression

Active Effects:

light depression reduction (acute effects; long term no notable improvement in quality of life)
light potenciation of dextroamphetamine through CYP2D6 inhibition

Legal status []

Australia: Fluoxetine is a S4 substance.^[3]
Brazil: Fluoxetine is a C1 substance.
Canada: Fluoxetine is a prescription only substance.
United Kingdom: Fluoxetine is a prescription only substance.
United States: Fluoxetine is a prescription only substance.
European Union: Fluoxetine is a prescription only substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 3386, Fluoxetine. Accessed April 15, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3386
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Fluoxetine. UNII: 01K63SUP8D. Global Substance Registration System. Accessed April 15, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/01K63SUP8D
Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. June 21, 2022. Accessed April 15, 2026. https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017

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