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Diacetylmorphine

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Heroin
Diacetylmorphine
[]
Diacetylmorphine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
[]
Conformer structure via 3Dmol.js
Enable javascript to view conformer structure via 3Dmol.js
Physical properties
[]
369.4 g/mol [1]
Density1.56 g/cu cm at 25 °C g/cm3 [1]
AppearanceOrthorhombic plates, tablets from ethyl acetate [1]
OdorOdorless [1]
TasteBitter [1]
Melting point173 °C [1]
Boiling point272-274 °C at 1.20E+01 mm Hg [1]
Decomposition... Decomposes by boiling with water. [1]
SolubilityIn water, 60 mg/L at 25 °C [1]
1.5 [1]
Structural Identifiers
[]
C21H23NO5 [1]
[(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate [1]
CC(=O)O[C@H]1C=C[C@H]2[C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)OC(=O)C)CCN3C [1]
InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1 [1]
InChIKeyGVGLGOZIDCSQPN-PVHGPHFFSA-N [1]
Pharmacokinetics[]
Elimination half-life2 – 3 minutes[3]
Duration of action4 – 5 hours[4]
Dosing[]
Insufflated
[]
Light≤ 14 mg(49x - 27.4%)
Common14 - 18 mg(42x - 23.5%)
Strong18 - 25 mg(49x - 27.4%)
Heavy25 - 32.6 mg(21x - 11.7%)
Extreme32.6 mg +(18x - 10.1%)
Intramuscular
[]
Light≤ 100 mg(4x - 80%)
Common100 mg
Strong100 mg
Heavy100 - 160 mg
Extreme160 mg +(1x - 20%)
Intrarectal
[]
Light≤ 18.3 mg(107x - 35.1%)
Common18.3 - 22.5 mg(47x - 15.4%)
Strong22.5 - 32 mg(78x - 25.6%)
Heavy32 - 47.2 mg(42x - 13.8%)
Extreme47.2 mg +(31x - 10.2%)
Vaporized
[]
Light≤ 33.9 mg(1x - 33.3%)
Common33.9 - 50 mg(1x - 33.3%)
Strong50 - 100 mg
Heavy100 - 130 mg
Extreme130 mg +(1x - 33.3%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

(Redirected from diamorphine)

Diacetylmorphine (also known as Heroin, Diamorphine, Acetomorphine, 3,6-Diacetylmorphine, Morphacetin, Diaphorm, Eclorion, O,O'-Diacetylmorphine, Morphine diacetate or Acetomorfine) is a prodrug and opioid substance of the morphinan class.

Chemistry

Salts []

Diacetylmorphine is typically found in the form of its hydrochloride salt.

 []

Diacetylmorphine is a absolute mixture.

There are currently 14 reagent-interactions on

ReagentColor change
Marquis
Mandelin
Liebermann
Marquis
Mecke
Mandelin
Liebermann
Froehde
Robadope
Simon's
Ehrlich
Hofmann
Scott
Morris

Pharmacology

In the () diacetylmorphine acts as a diamorphine (), drugs used in addictive disorder (), drugs used in opioid dependence () and other nervous system drug ().[1]

Metabolism

Diacetylmorphine acts as a for:

Metabolic pathways []
>
Diacetylmorphine
Diacetylmorphine


Subjective effects []

Mere / Diacetylmorphine []
bonzi / Diacetylmorphine []
Routes:
  • Insufflated (5 - 30mg)
  • Intravenous (5 - 25mg)
  • Vaporized (20 - 40mg)
Salts:
  • Hydrochloride
Source:
  • Heroin #4 (hcl) from Thailand
a1ko / Diacetylmorphine []
Routes:
  • Smoked
  • Intravenous (10 - 75mg)
Effects:
0xea / Diacetylmorphine []
Routes:
  • Vaporized (10 - 70mg)
    Onset: 5 - 15 s
    Comeup: 1 - 5 m
    Duration: 3 - 5 h
  • Intravenous (5 - 50mg)
    Onset: 10 - 20 s
    Comeup: 1 - 5 m
    Duration: 3 - 5 h
Salts:
  • Freebase
  • Citrate
  • Ascorbate
  • D-Tartrate
Indication:Effects:
  • Intravenous
After Effects:Tolerance:
  • builds steadily over the span of 1-2 weeks
Notes:
  • generally has a negative impact on productivity and long-term wellbeing but can be helpful in change of perspective and acute coping
  • plesant to foil

Experience reports

Erowid

There are currently 26 experience reports involving diacetylmorphine on : []

 []

  • Australia: Diacetylmorphine is a S9 substance.
  • Brazil: Diacetylmorphine is a F1 substance.
  • Canada: Diacetylmorphine is a Schedule I controlled substance|Schedule I substance.
  • Germany: Diacetylmorphine is a Anlage I, Anlage II|II and Anlage III|III substance.
  • New Zealand: Diacetylmorphine is a Class A substance.
  • United Kingdom: Diacetylmorphine is a Class A substance.
  • United States: Diacetylmorphine is a Schedule I under the "Controlled Substances Act (CSA)".
  • United Nations: Diacetylmorphine is a Narcotic Schedules I and IV substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5462328, Diacetylmorphine. Accessed May 24, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5462328

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Diacetylmorphine. UNII: 70D95007SX. Global Substance Registration System. Accessed May 24, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/70D95007SX

  3. Diamorphine Hydrochloride 10mg for Injection. May 6, 2020. Accessed May 24, 2026. https://www.medicines.org.uk/emc/product/1466/smpc

  4. Field J. The Textbook of Emergency Cardiovascular Care and CPR. Lippincott Williams & Wilkins. 2012. Accessed May 24, 2026. https://books.google.com/books?id=o3m4oNRB4D4C&pg=PA447