Diacetylmorphine (Heroin)

Heroin

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	369.4 g/mol ^[1]
Density	1.56 g/cu cm at 25 °C g/cm³ ^[1]
Appearance	Orthorhombic plates, tablets from ethyl acetate ^[1]
Odor	Odorless ^[1]
Taste	Bitter ^[1]
Melting point	173 °C ^[1]
Boiling point	272-274 °C at 1.20E+01 mm Hg ^[1]
Decomposition	... Decomposes by boiling with water. ^[1]
Solubility	In water, 60 mg/L at 25 °C ^[1]
Predicted LogP	1.5 ^[1]

Structural Identifiers []
Molecular formula	C₂₁H₂₃NO₅ ^[1]
IUPAC name	[(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate ^[1]
SMILES	CC(=O)O[C@H]1C=C[C@H]2[C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)OC(=O)C)CCN3C ^[1]
InChI	InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1 ^[1]
InChIKey	GVGLGOZIDCSQPN-PVHGPHFFSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	2 – 3 minutes^[3]
Duration of action	4 – 5 hours^[4]

Dosing[]

Insufflated []
Light	≤ 14 mg(49x - 27.4%)
Common	14 - 18 mg(42x - 23.5%)
Strong	18 - 25 mg(49x - 27.4%)
Heavy	25 - 32.6 mg(21x - 11.7%)
Extreme	32.6 mg +(18x - 10.1%)

Intramuscular []
Light	≤ 100 mg(4x - 80%)
Common	100 mg
Strong	100 mg
Heavy	100 - 160 mg
Extreme	160 mg +(1x - 20%)

Intrarectal []
Light	≤ 18.3 mg(107x - 35.1%)
Common	18.3 - 22.5 mg(47x - 15.4%)
Strong	22.5 - 32 mg(78x - 25.6%)
Heavy	32 - 47.2 mg(42x - 13.8%)
Extreme	47.2 mg +(31x - 10.2%)

Vaporized []
Light	≤ 33.9 mg(1x - 33.3%)
Common	33.9 - 50 mg(1x - 33.3%)
Strong	50 - 100 mg
Heavy	100 - 130 mg
Extreme	130 mg +(1x - 33.3%)

Statistically derived dosages via DBI-IGS

We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Diacetylmorphine (also known as Heroin, Diacetylmorphine, Diamorphine, Acetomorphine, 3,6-Diacetylmorphine, Morphacetin, Diaphorm, Eclorion, O,O'-Diacetylmorphine or Morphine diacetate) is a prodrug and opioid substance of the morphinan class.

Chemistry

Pharmacology

ATC Classification

Metabolism

Metabolic pathways []
> Diacetylmorphine Morphine 6-Monoacetylmorphine

Subjective effects []

class / Prodrug Opioid

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

bonzi / Diacetylmorphine []
Routes: Insufflated (5 - 30mg) Intravenous (5 - 25mg) Vaporized (20 - 40mg) Salts: Hydrochloride Source: Heroin #4 (hcl) from Thailand

bonzi / Diacetylmorphine []

Routes:

Insufflated (5 - 30mg)
Intravenous (5 - 25mg)
Vaporized (20 - 40mg)

Salts:

Hydrochloride

Source:

Heroin #4 (hcl) from Thailand

0xea / Diacetylmorphine []
Routes: Vaporized (10 - 70mg) Onset: 5 - 15 s Comeup: 1 - 5 m Duration: 3 - 5 h Intravenous (10 - 40mg) Onset: 10 - 20 s Comeup: 1 - 5 m Duration: 3 - 5 h Salts: Freebase Citrate Ascorbate D-Tartrate Indication: pain anxiety panic attack fear of abandonment Active Effects: moderate sedation strong anxiety suppression moderate cognitive euphoria disinhibition light analysis suppression perception of bodily heaviness pain relief helps deal with siginificant emotional pain double vision motor control loss moderate thought deceleration moderate tinnitus auditory suppression increased bodily temperature increased perspiration moderate compulsive redosing dream like states which feel fully concious/lucid increased libido muscle relaxation pupil constriction light appetite enhancement Side Effects: irritability constipation nausea dizziness vomiting After Effects: constipation pain sensitization back pain depression opioid withdrawal Notes: generally has a negative impact on productivity and long-term wellbeing but can be helpful in change of perspective and acute coping plesant to foil intravenously smoother/weaker rush than morphine

0xea / Diacetylmorphine []

Routes:

Vaporized (10 - 70mg)
Onset: 5 - 15 s
Comeup: 1 - 5 m
Duration: 3 - 5 h
Intravenous (10 - 40mg)
Onset: 10 - 20 s
Comeup: 1 - 5 m
Duration: 3 - 5 h

Salts:

Freebase
Citrate
Ascorbate
D-Tartrate

Indication:

pain
anxiety
panic attack
fear of abandonment

Active Effects:

moderate sedation
strong anxiety suppression
moderate cognitive euphoria
disinhibition
light analysis suppression
perception of bodily heaviness
pain relief
helps deal with siginificant emotional pain
double vision
motor control loss
moderate thought deceleration
moderate tinnitus
auditory suppression
increased bodily temperature
increased perspiration
moderate compulsive redosing
dream like states which feel fully concious/lucid
increased libido
muscle relaxation
pupil constriction
light appetite enhancement

Side Effects:

After Effects:

Notes:

generally has a negative impact on productivity and long-term wellbeing but can be helpful in change of perspective and acute coping
plesant to foil
intravenously smoother/weaker rush than morphine

Legal status []

Australia: Diacetylmorphine is a S9 substance.
Brazil: Diacetylmorphine is a F1 substance.
Canada: Diacetylmorphine is a Schedule I controlled substance|Schedule I substance.
Germany: Diacetylmorphine is a Anlage I, Anlage II|II and Anlage III|III substance.
New Zealand: Diacetylmorphine is a Class A substance.
United Kingdom: Diacetylmorphine is a Class A substance.
United States: Diacetylmorphine is a Schedule I under the "Controlled Substances Act (CSA)".
United Nations: Diacetylmorphine is a Narcotic Schedules I and IV substance.

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 5462328, Heroin. Accessed April 16, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5462328
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Diacetylmorphine. UNII: 70D95007SX. Global Substance Registration System. Accessed April 16, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/70D95007SX
Diamorphine Hydrochloride 10mg for Injection. May 6, 2020. Accessed April 16, 2026. https://www.medicines.org.uk/emc/product/1466/smpc
Field J. The Textbook of Emergency Cardiovascular Care and CPR. Lippincott Williams & Wilkins. 2012. Accessed April 16, 2026. https://books.google.com/books?id=o3m4oNRB4D4C&pg=PA447

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Diacetylmorphine