Anodyne| Pregabalin | |
|---|---|
 | |
| Molecular structure via molpic based on CDK |
| Conformer [] | |
|---|---|
| Physical properties [] | |
|---|---|
| Molecular mass | 159.23 g/mol [1] |
| Appearance | White to off-white crystalline solid [1] |
| Melting point | 186-188 °C [1] |
| Solubility | Freely soluble [1] |
| Predicted LogP | -1.6 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C8H17NO2 [1] |
| IUPAC name | (3S)-3-(aminomethyl)-5-methylhexanoic acid [1] |
| SMILES | CC(C)C[C@@H](CC(=O)O)CN [1] |
| InChI | InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 [1] |
| InChIKey | AYXYPKUFHZROOJ-ZETCQYMHSA-N [1] |
| Dosing [] | |
|---|---|
| Elimination half-life | 4.5 – 7 hours[4] (mean 6.3 hours)[5] |
| Duration of action | 8 – 12 hours [6] |
Pregabalin
Pregabalin (also known as (S)-3-(Aminomethyl)-5-methylhexanoic acid, 3-isobutyl GABA, (S)-Pregabalin, Pregabalina, Pregabaline, Vronogabic, Pregabalin mylan, Pregabalin sandoz, Pregabalin zentiva or Pregabalin sandoz gmbh) is a
Chemistry
Salts []
Pregabalin is typically found in the form of its hydrochloride and sodium salts.
Stereochemistry []
Pregabalin is a absolute mixture
| Anodyne Usernotes [] | |
|---|---|
| 0xea / Pregabalin via | Baseline Anxiety suppression; doesn't prevent Sensory overload |
Experience reports []
There are currently 25+ experience reports involving pregabalin on OpenErowid:
- "Observations Over 4 Years of Usage"
- "Amazing Time Slip"
- "My Hellish Withdrawal"
- "I Wish I Hadn't Redosed"
- "Painless Time and Zoned Out"
- "My Social Anxiety Has Been Obliterated"
- "Long-Term Use and High Dosages"
- "Closed Eye Visuals Similar to Lucid Dreaming"
- "Wishing It Never Ended"
- "All in Around 5 Years"
- "On a Dose for a Traumatic Brain Injury"
- "A Very Romantic Night With My Wife"
- "Gentle and Smooth"
- "Ghost In My Kitchen"
- "Cannabis Type Buzz"
- "The Journey Into Acceptance"
- "Mildly Dissociative"
- "Personal Effects Summary"
- "I Can Alter the Scene-Flow"
- "Cutting-Edge Pharmacology a Double-Edged Swor"
- "Effects Peaked Around the Two Hour Mark"
- "Body Warmth and Pleasantness of Mind"
- "A Little Too Much"
- "Zero Recreational Benefits"
- "Maybe Mania"
Legal status
- Australia: Pregabalin is a S4 substance.[3]
- Brazil: Pregabalin is a C1 substance.
- Canada: Pregabalin is a prescription only substance.
- New Zealand: Pregabalin is a prescription only substance.
- United Kingdom: Pregabalin is a prescription only substance.
- United States: Pregabalin is a Schedule V substance.
- European Union: Pregabalin is a prescription only substance.
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 5486971, Pregabalin. Accessed June 26, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5486971
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pregabalin. UNII: 55JG375S6M. Global Substance Registration System. Accessed June 26, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/55JG375S6M
Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. June 21, 2022. Accessed June 26, 2025. https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-generic-medicines-and-biosimilar-medicines-2017
Expert Committee on Drug Dependence Forty-first Meeting. Critical Review Report: Pregabalin. World Health Organization. November 1, 2018. Accessed June 26, 2025. https://www.who.int/medicines/access/controlled-substances/Pregabalin_FINAL.pdf?ua=1
Cross AL, Viswanath O, Sherman AI. StatPearls [Internet]. StatPearls Publishing. July 19, 2022. Accessed June 26, 2025. https://www.ncbi.nlm.nih.gov/books/NBK470341/
BNF Pregabalin. NICE. November 16, 2018. Accessed June 26, 2025. https://bnf.nice.org.uk/drugs/pregabalin/#indications-and-dose