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Domperidone

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Domperidone
Domperidone
Salts
[]
Domperidone maleate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Domperidone acetate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
Conformer structure via 3Dmol.js
Enable javascript to view conformer structure via 3Dmol.js
Physical properties
[]
425.9 g/mol [1]
Melting point242.5 °C [1]
Solubility9.25e-02 g/L [1]
3.9 [1]
Structural Identifiers
[]
C22H24ClN5O2 [1]
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one [1]
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O [1]
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) [1]
InChIKeyFGXWKSZFVQUSTL-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life7 – 9 hours
Dosing[]
Oral
[]
Light≤ 11 mg(111x - 66.1%)
Common11 mg
Strong10 - 20 mg(56x - 33.3%)
Heavy20 mg
Extreme20 mg +(1x - 0.6%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Domperidone (also known as Motilium, Domperidona, Domperidonum, R 33,812, R-33812, NSC299589, NSC-299589, KW 5338, NSC-759575 or 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone) is a substance of the aniline class.

Chemistry

Salts []

Domperidone is typically found in the form of its maleate and acetate salts.

 []

Domperidone is a achiral mixture.

Domperidone matches Lipinski's rule of five.

Pharmacology

In the () domperidone acts

Subjective effects []

0xea / Domperidone []
Routes:
  • Oral (10 - 20mg)
Indication:Effects:

 []

  • Australia: Domperidone is a S4 substance.
  • Canada: Domperidone is a prescription only substance.[3]
  • United Kingdom: Domperidone is a prescription only substance.
  • European Union: Domperidone is a prescription only substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 3151, Domperidone. Accessed June 13, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3151

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Domperidone. UNII: 5587267Z69. Global Substance Registration System. Accessed June 13, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5587267Z69

  3. Motilium product information. January 7, 2002. Accessed June 13, 2026. https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=10691