Domperidone
| Domperidone | |
|---|---|
 |
| Salts [] | |
|---|---|
| Domperidone maleate | |
| Domperidone acetate | |
| Molecular structure via molpic based on CDK |
| Physical properties [] | |
|---|---|
| Molecular mass | 425.9 g/mol [1] |
| Melting point | 242.5 °C [1] |
| Solubility | 9.25e-02 g/L [1] |
| Predicted LogP | 3.9 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C22H24ClN5O2 [1] |
| IUPAC name | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one [1] |
| SMILES | C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O [1] |
| InChI | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) [1] |
| InChIKey | FGXWKSZFVQUSTL-UHFFFAOYSA-N [1] |
| Pharmacokinetics[] | |
|---|---|
| Elimination half-life | 7 – 9 hours |
| Dosing[] |
|---|
| Oral [] | |
|---|---|
| Light | ≤ 11 mg(111x - 66.1%) |
| Common | 11 mg |
| Strong | 10 - 20 mg(56x - 33.3%) |
| Heavy | 20 mg |
| Extreme | 20 mg +(1x - 0.6%) |
Statistically derived dosages via DBI-IGS We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly. |
Domperidone (also known as Motilium, Domperidona, Domperidonum, R 33,812, R-33812, NSC299589, NSC-299589, KW 5338, NSC-759575 or 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone) is a
Chemistry
Stereochemistry []
Domperidone is a achiral mixture.
Druglikeness
Lipinski's rule of five
Domperidone matches Lipinski's rule of five.Pharmacology
ATC Classification
In the alimentary tract and metabolism (A) domperidone actsSubjective effects []
| 0xea / Domperidone [] | |
|---|---|
Routes:
| |
Legal status []
- Australia: Domperidone is a S4 substance.
- Canada: Domperidone is a prescription only substance.[3]
- United Kingdom: Domperidone is a prescription only substance.
- European Union: Domperidone is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 3151, Domperidone. Accessed June 13, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3151
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Domperidone. UNII: 5587267Z69. Global Substance Registration System. Accessed June 13, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5587267Z69
Motilium product information. January 7, 2002. Accessed June 13, 2026. https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=10691