{"ATC Code":["A - Alimentary tract and metabolism","A03 - Drugs for functional gastrointestinal disorders","A03F - Propulsives","A03FA - Propulsives","A03FA03","A03FA03 - Domperidone","QA - Alimentary tract and metabolism","QA03 - Drugs for functional gastrointestinal disorders","QA03F - Propulsives","QA03FA - Propulsives","QA03FA03 - Domperidone","QP - Antiparasitic products, insecticides and repellents","QP51 - Antiprotozoals","QP51D - Agents against leishmaniosis and trypanosomosis","QP51DX - Other agents against leishmaniosis and trypanosomosis","QP51DX06 - Domperidone"],"Aliases":["Motilium","Domperidona","Domperidonum","R 33,812","R-33812","NSC299589","NSC-299589","KW 5338","NSC-759575","5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone","Dtxcid9025116","Chebi:31515","5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone","Apo Domperidone","2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-","5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one","Domperidon","Motilium 10","R33812","1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one","2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-","5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one","5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one","5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one","Evoxin","Domilium","Equidone","Vivadone","Nu Domperidone","Equidone Gel","Novo Domperidone","PMS Domperidone","Motilium instants","ratio Domperidone","Domperidon TEVA","Hexal, Domperidon","Stada, Domperidon","Gamir, Domperidona","1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo(d)imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo(d)imidazol-2(3H)-one","5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one","5-Chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one","5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl)-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one","5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo(d)imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo(d)imidazol-2(3H)-one","6-chloro-3-(1-(3-(2-oxo-3H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1H-benzimidazol-2-one","Maleate, Domperidone","Monohydrochloride, Domperidone","A03FA03","R33,812","260-968-7","Nauzelin","5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one","Mfcd00069256","4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine","Mls000069343","Chembl219916","s2461","5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one","Motinorm","Costi","C22H24ClN5O2","Motillium","KW-5338","Smr000326802","Cas-57808-66-9","Lopac-D-122","Sr-01000003002","Einecs 260-968-7","Brn 0903774","Domperidone CRS","Nauzelin OD","5-chloro-1-{1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one","Prestwick_794","NCI299589","HS-0067","Spectrum_000391","A1IVJ","Opera_ID_616","SpecPlus_000825","Domperidone, pharma grade","Prestwick0_000461","Prestwick1_000461","Prestwick2_000461","Prestwick3_000461","Spectrum4_000087","Biomol-NT_000022","NCIStruc1_001686","NCIStruc2_001819","Lopac0_000427","R 33812","Schembl43729","BSPBio_002350","GTPL965","KBioGR_000354","KBioSS_000871","5-24-02-00402","Mls000859942","Mls001306482","Mls002222324","DivK1c_006921","Spectrum2300212","SPBio_002501","BPBio1_000620","BPBio1_001185","orb1310958","Schembl29373565","HY-B0411R","KBio1_001865","KBio2_000871","KBio2_003439","KBio2_006007","HMS1922N04","HMS2089C14","HMS2093N22","HMS2096C21","HMS2230N18","HMS3261E16","HMS3269O13","HMS3370L03","HMS3413F15","HMS3656M21","HMS3677F15","HMS3713C21","HMS3884N19","HMS5081K07","Pharmakon1600-02300212","Domperidone 1.0 mg/ml in Methanol","HY-B0411","MSK10219","Tox21_110056","Tox21_500427","Bdbm50241107","CCG-37870","EBC-11171","HB1888","Ncgc00014670","NSC759575","STK622843","Akos005555858","Tox21_110056_1","AC-2037","DB01184","Domperidone, powder, \u003e=98%","FD31879","LP00427","NSC 299589","NSC 759575","Sdccgsbi-0050412.p004","6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]-4-piperidyl]-1H-benzimidazol-2-one","Ncgc00014670-01","Ncgc00014670-02","Ncgc00014670-03","Ncgc00014670-04","Ncgc00014670-05","Ncgc00014670-06","Ncgc00014670-07","Ncgc00014670-08","Ncgc00014670-09","Ncgc00014670-10","Ncgc00014670-11","Ncgc00014670-12","Ncgc00014670-13","Ncgc00014670-14","Ncgc00014670-16","Ncgc00014670-17","Ncgc00014670-23","Ncgc00014670-28","Ncgc00015306-01","Ncgc00021472-02","Ncgc00021472-03","Ncgc00021472-04","Ncgc00021472-05","Ncgc00021472-06","Ncgc00021472-07","Ncgc00021472-08","Ncgc00097773-01","Ncgc00261112-01","5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one","5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one","BD164379","Nci60_002512","Smr000058969","SY052451","AB00052423","D4125","D5649","EU-0100427","NS00002818","SW196931-3","C75710","D01745","Ab00052423-06","Ab00052423-07","Ab00052423_08","Ab00052423_09","En300-7411248","L000230","Sr-01000003002-2","Sr-01000003002-4","Sr-01000003002-7","Brd-k38305202-001-02-6","Brd-k38305202-001-08-3","Brd-k38305202-001-16-6","Brd-k38305202-001-17-4","Brd-k38305202-001-18-2","Domperidone, European Pharmacopoeia (EP) Reference Standard","5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one","1H-Benzimidazol-2-ol, 5-chloro-1-[1-[3-(2-hydroxy-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-","2H-Benzimidazol-2-one,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-","5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1-benzoimidazolyl)propyl]-4-piperidyl]-1H-benzo[d]imidazol-2(3H)-one","5-chloro-1-{1-[3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one","5-Chloro-1-{1-[3-(2-hydroxy-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-2,3-dihydro-1H-benzoimidazol-2-ol","5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-1,3-benzimidazol-2-one","5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one(domperidone)","DOMPERIDONE5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one"],"Biological Half-Life":"7 hours","CAS":"57808-66-9","ChemicalClasses":["aniline"],"Chirality":"achiral","DBI-IGS":["Domperidone"],"DTXSID":"1045116","Dosing Info":[{"Method":"Oral","Tiers":{"Common":{"Entries":0,"Lower":11,"Percentage":0,"Unit":"mg","Upper":10},"Extreme":{"Entries":1,"Lower":20,"Percentage":0.6,"Unit":"mg","Upper":20},"Heavy":{"Entries":0,"Lower":20,"Percentage":0,"Unit":"mg","Upper":20},"Light":{"Entries":111,"Lower":11,"Percentage":66.1,"Unit":"mg","Upper":11},"Strong":{"Entries":56,"Lower":10,"Percentage":33.3,"Unit":"mg","Upper":20}}}],"Drug Classes":["Breast Feeding","Lactation","Milk, Human","Antiemetics","Dopamine Antagonists","Galactogogues","Gastrointestinal Agents"],"Drug Indication":"For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.","Druglikeness":{"Lipinski":{"Passes":true,"Violations":0}},"DurationOfAction":"","EliminationHalfLife":"7 – 9 hours","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"260-968-7","Formating":[],"HMDB ID":"HMDB0015315","HeavyAtomCount":30,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Antiemetics; Dopamine Antagonists; Galactogogues; Gastrointestinal Agents","IUPACName":"6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one","InChI":"InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)","InChIKey":"FGXWKSZFVQUSTL-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0006752","Link":"https://id.nlm.nih.gov/mesh/M0006752.html","Name":"Domperidone","Ref":84},{"Id":"M0006753","Link":"https://id.nlm.nih.gov/mesh/M0006753.html","Name":"Motilium","Ref":86},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":87},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":112},{"Id":"M0001391","Link":"https://id.nlm.nih.gov/mesh/M0001391.html","Name":"Antiemetics","Ref":113},{"Id":"M0027734","Link":"https://id.nlm.nih.gov/mesh/M0027734.html","Name":"Dopamine Antagonists","Ref":114}],"MeSH Pharmacological Classification":[{"Id":"M0001391","Link":"https://id.nlm.nih.gov/mesh/M0001391.html","Name":"Antiemetic","Ref":113},{"Id":"M0027734","Link":"https://id.nlm.nih.gov/mesh/M0027734.html","Name":"Dopamine Antagonist","Ref":114}],"Mechanism of Action":"Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting","Melting Point":"242.5 °C","Metabolism/Metabolites":"Domperidone has known human metabolites that include 1-Propyl-1,3-dihydro-2H-benzimidazol-2-one, 5-Chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, and 3-[3-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-6-hydroxy-1H-benzimidazol-2-one.","MolecularFormula":"C\u003csub\u003e22\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eClN\u003csub\u003e5\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"425.9 g/mol","Passes":true,"Pharmacodynamics":"Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.","Physical Description":"Solid","PubChemId":3151,"PubChemTitle":"Domperidone","Record Description":["LiverTox|Gastroinestinal|Prokinetic agent|Antidopaminergic"],"Records":{"UNII":{"Impurities":["5-chloro-1-(4-piperidinyl)-2-benzimidazolinone","4-(5-chloro-2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)-1-formylpiperidine","1,3-bis(3-(4-(5-chloro-2-oxo-3h-benzimidazol-1-yl)piperidin-1-yl)propyl)benzimidazol-2-one","1-(3-(4-(5-chloro-2-oxo-3h-benzimidazol-1-yl)piperidin-1-yl)propyl)-3-(3-(2-oxo-3h-benzimidazol-1-yl)propyl)benzimidazol-2-one","5-chloro-3-(3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl)-1-(1-(3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl) propyl) piperidin-4-yl)- 1,3-dihydro-2h-benzimidazol-2-one"]}},"RefChem":"5776","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Domperidone","Name":"Domperidone","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q424238","Name":"Domperidone","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01184","Name":"Domperidone","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3151","Name":"Domperidone","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=57808-66-9","Name":"Domperidone","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015315","Name":"Domperidone","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01745","Name":"Domperidone","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/5587267Z69","Name":"Domperidone","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1045116","Name":"Domperidone","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3151, Domperidone. Accessed June 13, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3151\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3151\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Domperidone. UNII: 5587267Z69. Global Substance Registration System. Accessed June 13, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5587267Z69\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/5587267Z69\u003c/a\u003e","Motilium product information. January 7, 2002. Accessed June 13, 2026. \u003ca href=https://health-products.canada.ca/dpd-bdpp/info?lang=eng\u0026code=10691\u003ehttps://health-products.canada.ca/dpd-bdpp/info?lang=eng\u0026code=10691\u003c/a\u003e"],"SMILES":"C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O","SaltData":[{"AcidCount":1,"Amine":"Domperidone","AmineCount":1,"Formula":"O=C(O)CC(O)C(=O)O","Name":"maleate","RName":"maleate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 286.888 74.219\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h287v75H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m76.449 55.576 14.907 3.171M91.356 58.747l7.237-8.042M100.252 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