Anodyne

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MXE
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
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Methoxetamine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
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Physical properties
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247.33 g/mol [1]
2.3 [1]
Structural Identifiers
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C15H21NO2 [1]
2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one [1]
CCNC1(CCCCC1=O)C2=CC(=CC=C2)OC [1]
InChI=1S/C15H21NO2/c1-3-16-15(10-5-4-9-14(15)17)12-7-6-8-13(11-12)18-2/h6-8,11,16H,3-5,9-10H2,1-2H3 [1]
InChIKeyLPKTWLVEGBNOOX-UHFFFAOYSA-N [1]
Dosing
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Elimination half-life3 – 6 hours

Methoxetamine

Methoxetamine (also known as cyclohexanone, 2-(ethylamino)-2-(3-methoxyphenyl)-, 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone, RefChem:157044, Mexxy, 3-MeO-2-Oxo-PCE, (RS)2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone, MXE, 2-(ethylaMino)-2-(3-Methoxyphenyl)-1-cyclohexanone, 2-(Ethylamino)-2-(3-methoxyphenyl)cyclohexanone or Cyclohexanone, 2-(ethylamino)-2-(3-methoxyphenyl)-; 2-(Ethylamino)-2-(3-methoxyphenyl)cyclohexanone; Methoxetamine; MXE) is a substance of the arylcyclohexylamine class.

Chemistry

Salts []

Methoxetamine is typically found in the form of its hydrochloride salt.

 []

Methoxetamine is a racemic mixture of the

Stereoisomers
(R)-MethoxetamineGenerated by the Chemistry Development Kit (http://github.com/cdk)
(S)-MethoxetamineGenerated by the Chemistry Development Kit (http://github.com/cdk)

Legal status []

  • Brazil: Methoxetamine is a F2 substance.
  • United Kingdom: Methoxetamine is a Class B substance.
  • United States: Methoxetamine is a Controlled Substances Act#Schedule I|Schedule I{-{cite web |title=Federal Register |date=6 June 2022 |url=https://www.federalregister.gov/documents/2022/06/06/2022-11933/schedules-of-controlled-substances-placement-of-methoxetamine-mxe-in-schedule-i |publisher=FederalRegister.gov|access-date=21 June 2022}-} substance.
  • Germany: Methoxetamine is a Anlage I substance.
  • United Nations: Methoxetamine is a Schedule II drug under the "Convention on Psychotropic Substances 1971".

See also []

  • Substituted arylcyclohexylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 52911279, Methoxetamine. Accessed September 6, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/52911279

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Methoxetamine. UNII: ZO5ZCE6E12. Global Substance Registration System. Accessed September 6, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/ZO5ZCE6E12