Vyvanse

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	263.38 g/mol ^[1]
Appearance	Golden-colored solid from methanol ^[1]
Melting point	191-193 ^[1]
Solubility	White to off-white powder. MP 120-122 °C. Solubility in water: 792 mg/mL /Lisdexamfetamine dimethanesulfonate/ ^[1]
Predicted LogP	1.2 ^[1]

Structural Identifiers []
Molecular formula	C₁₅H₂₅N₃O ^[1]
IUPAC name	(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide ^[1]
SMILES	C[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)N ^[1]
InChI	InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1 ^[1]
InChIKey	VOBHXZCDAVEXEY-JSGCOSHPSA-N ^[1]

Lisdexamphetamine

Lisdexamphetamine (also known as Lisdexamfetamine, lysine-d-amphetamine, lisdexanfetamina, lysine-dextroamphetamine, (2S)-2,6-Diamino-N-((1S)-1-methyl-2-phenylethyl)hexanamide, (2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide, (2S)-2,6-diamino-N-((2S)-1-phenylpropan-2-yl)hexanamide, lisdexamfetaminum, (2S)-2,6-diamino-N-((2S)-1-phenylpropan-2-yl)hexanimidic acid or (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanimidic acid) is a codrug, prodrug and stimulant substance of the amphetamine class.

Chemistry

Stereochemistry []

Lisdexamphetamine is a achiral mixture

Pharmacology

Lisdexamphetamine acts as a codrug for:

Active metabolites []
Lysine Dextroamphetamine

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Anodyne Usernotes []
0xea / Lisdexamphetamine^[dimesylate] via Oral and Intravenous	Prodrug to Dextroamphetamine; Moderate Stimulation; Moderate Euphoria; Minimal Vasoconstriction

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 11597698, Lisdexamphetamine. Accessed July 22, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/11597698