Anodyne

Dimenhydrinate
Dimenhydrinate
Molecular structure via molpic based on CDK
Physical properties
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470.0 g/mol [1]
AppearanceCRYSTALS [1]
OdorODORLESS [1]
Melting point216 to 225 °F (NTP, 1992) [1]
SolubilitySlightly soluble (1-10 mg/ml at 72 °F) (NTP, 1992) [1]
Structural Identifiers
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C24H28ClN5O3 [1]
2-benzhydryloxy-N,N-dimethylethanamine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione [1]
CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 [1]
InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10) [1]
InChIKeyNFLLKCVHYJRNRH-UHFFFAOYSA-N [1]
Dosing
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Elimination half-life5.5 hours[3] (diphenhydramine component)

Dimenhydrinate

Dimenhydrinate (also known as Travelin, Chloranautine, Diphenhydrinate, Vomex A, Anautine, Amosyt, Menhydrinate, Andramine, Diamarin or Dimenest) is a substance of the xanthine class.

Chemistry

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Dimenhydrinate is a achiral mixture

Anodyne Usernotes
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0xea / Dimenhydrinate via Nothing to note

Experience reports []

Legal status []

  • Australia: Dimenhydrinate is a S2 substance.
  • Canada: Dimenhydrinate is a Over-the-counter drug|OTC substance.
  • United States: Dimenhydrinate is a OTC substance.

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 10660, Dimenhydrinate. Accessed June 26, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/10660

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dimenhydrinate. UNII: JB937PER5C. Global Substance Registration System. Accessed June 26, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/JB937PER5C

  3. Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ. Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration. Biopharmaceutics & Drug Disposition. April 1, 1990; 11(3):185–189.