Anodyne

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Sulpiride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
[]
Sulpiride hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
341.4 g/mol [1]
Melting point178 °C [1]
Solubility>51.2 [ug/mL] (The mean of the results at pH 7.4) [1]
0.6 [1]
Structural Identifiers
[]
C15H23N3O4S [1]
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide [1]
CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC [1]
InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21) [1]
InChIKeyBGRJTUBHPOOWDU-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life6 – 8 hours[4]
Toxicity
[]
Human:
- oral: 2143 μg/kg/D
- intramuscular: 1429 μg/kg/D
Rat:
- oral: 9800 mg/kg
- intraperitoneal: 210 mg/kg
- subcutaneous: 360 mg/kg
- intravenous: 40 mg/kg
Mouse:
- oral: 1700 mg/kg
- intraperitoneal: 170 mg/kg
- subcutaneous: 290 mg/kg
- intravenous: 48 mg/kg
Dog:
- oral: 2 gm/kg
- subcutaneous: 350 mg/kg
- intravenous: 137 mg/kg
Rabbit:
- oral: 4 gm/kg
- subcutaneous: 2 gm/kg
- intravenous: 63 mg/kg

Sulpiride

Sulpiride (also known as Sulpiride, sulpiride, Sulpyrid, Sulpirid, Aiglonyl, Dolmatil, Dogmatil, Guastil, Dogmatyl or Mirbanil) is a substance of the benzylamine class.

Chemistry

Salts []

Sulpiride is typically found in the form of its hydrochloride salt.

 []

Sulpiride is a racemic mixture of the

Stereoisomers
(R)-SulpirideGenerated by the Chemistry Development Kit (http://github.com/cdk)
(S)-SulpirideGenerated by the Chemistry Development Kit (http://github.com/cdk)

Legal status []

  • Brazil: Sulpiride is a C1 substance.[3]
  • United Kingdom: Sulpiride is a prescription only substance.

See also []

  • Substituted benzylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5355, Sulpiride. Accessed October 2, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5355

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Sulpiride. UNII: 7MNE9M8287. Global Substance Registration System. Accessed October 2, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7MNE9M8287

    3. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed October 2, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992

    4. Brès J, Bressolle F. Pharmacokinetics of sulpiride in humans after intravenous and intramuscular administrations. J Pharm Sci. December 1, 1991; 80(12):1119–24.