{"ATC Code":"N05AL01","Abbreviation":[],"Aliases":["Sulpiride","sulpiride","Sulpyrid","Sulpirid","Aiglonyl","Dolmatil","Dogmatil","Guastil","Dogmatyl","Mirbanil","Misulvan","Neogama","Omperan","Splotin","Sursumid","Abilit","Dobren","Meresa","Coolspan","Sernevin","Sulpitil","Sulpirida","Synedil","Pyrikappl","Sulpiridum"],"Biological Half-Life":"Reports of the half life of sulpiride have only been performed with small numbers of subjects. Therefore, the average half life may be 7.15 hours to 8.3 hours.","CAS":"15676-16-1","ChEBI":"CHEBI:32168","ChEMBL":"CHEMBL26","ChemicalClasses":["benzylamine"],"Chirality":"racemic","Drug Classes":"Breast Feeding; Lactation; Milk, Human; Antipsychotic Agents; Dopamine Antagonists","Drug Indication":"Sulpiride is indicated for the treatment of acute and chronic schizophrenia.","EINECS":"239-753-7","EliminationHalfLife":"6 – 8 hours\u003ca href='#cite_note-4'\u003e\u003csup\u003e[4]\u003c/sup\u003e\u003c/a\u003e","Esters":[],"European Community (EC) Number":"239-753-7","Formating":[],"HMDB ID":"HMDB0014535","HeavyAtomCount":23,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Antipsychotic Agents; Dopamine Antagonists","IUPACName":"N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide","Impurities":["chloride ion","iron","2-methoxy-5-sulfamoylbenzoic acid","2-methoxy-5-sulfamoylbenzamide","methyl 5-sulfamoyl-o-anisate","ethyl 5-sulphamoyl-o-anisate","1-ethyl-2-pyrrolidinemethanamine","benzamide, 5-(aminosulfonyl)-n-((1-ethyl-1-oxido-2-pyrrolidinyl)methyl)-2-methoxy-"],"InChI":"InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)","InChIKey":"BGRJTUBHPOOWDU-UHFFFAOYSA-N","LD50":[{"dosages":[{"amount":"9800 mg/kg","route":"oral"},{"amount":"210 mg/kg","route":"intraperitoneal"},{"amount":"360 mg/kg","route":"subcutaneous"},{"amount":"40 mg/kg","route":"intravenous"}],"organism":"Rat"},{"dosages":[{"amount":"1700 mg/kg","route":"oral"},{"amount":"170 mg/kg","route":"intraperitoneal"},{"amount":"290 mg/kg","route":"subcutaneous"},{"amount":"48 mg/kg","route":"intravenous"}],"organism":"Mouse"},{"dosages":[{"amount":"2 gm/kg","route":"oral"},{"amount":"350 mg/kg","route":"subcutaneous"},{"amount":"137 mg/kg","route":"intravenous"}],"organism":"Dog"},{"dosages":[{"amount":"4 gm/kg","route":"oral"},{"amount":"2 gm/kg","route":"subcutaneous"},{"amount":"63 mg/kg","route":"intravenous"}],"organism":"Rabbit"}],"MeSH Pharmacological Classification":"Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.","Melting Point":"178 °C","MolecularFormula":"C\u003csub\u003e15\u003c/sub\u003eH\u003csub\u003e23\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003eS","MolecularWeight":"341.4 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist indicated to treat acute and chronic schizophrenia. It has a short duration of action as it is given twice daily, and a wide therapeutic window as patients have survived single doses as high as 16g. Patients should be counselled regarding increased motor agitation, extrapyramidal reactions, and neuroleptic malignant syndrome.","Physical Description":"Solid","PubChemId":5355,"RefCount":5,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Sulpiride","Name":"Sulpiride","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q422418","Name":"Sulpiride","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00391","Name":"Sulpiride","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5355","Name":"Sulpiride","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL26","Name":"Sulpiride","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32168","Name":"Sulpiride","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=15676-16-1","Name":"Sulpiride","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014535","Name":"Sulpiride","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01226","Name":"Sulpiride","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/7MNE9M8287","Name":"Sulpiride","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1042574","Name":"Sulpiride","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5355, Sulpiride. Accessed October 2, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5355\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5355\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Sulpiride. UNII: 7MNE9M8287. Global Substance Registration System. Accessed October 2, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7MNE9M8287\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/7MNE9M8287\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed October 2, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e","Brès J, Bressolle F. Pharmacokinetics of sulpiride in humans after intravenous and intramuscular administrations. J Pharm Sci. December 1, 1991; 80(12):1119–24."],"SMILES":"CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC","SaltData":[{"AcidCount":1,"Amine":"Sulpiride","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 132.2 87.958\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h133v88H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m77.589 71.843-3.198-14.901M74.391 56.942l8.327-7.526M89.008 47.425l11.56 2.451M100.568 49.876l7.67-13.194M108.238 36.682 98.04 25.356M98.04 25.356l-13.992 6.173M85.28 42.881l-1.232-11.352M84.048 31.529l-13.198-7.62M70.85 23.909l-10.045 5.799M54.498 29.708l-10.045-5.799\" 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