Remifentanil

Remifentanil

Salts []
Remifentanil hydrochloride

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	376.4 g/mol ^[1]
Appearance	Oil ^[1]
Melting point	Crystals from methanol + ether. MP: 212-214 °C /Remifentanil hydrochloride/ ^[1]
Solubility	Soluble in methanol, ethyl acetate ^[1]
Predicted LogP	1.9 ^[1]

Structural Identifiers []
Molecular formula	C₂₀H₂₈N₂O₅ ^[1]
IUPAC name	methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate ^[1]
SMILES	CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC ^[1]
InChI	InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3 ^[1]
InChIKey	ZTVQQQVZCWLTDF-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	1 – 20 minutes

Remifentanil (also known as Remifentanil, Remifentanyl, ramifentanyl, GI 87084X, Ultiva-, Remifentanilo, IDS-NR-005, 4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester, methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate or CHEBI:8802) is a opioid substance of the amino acid class.

Chemistry

Salts []

Remifentanil is typically found in the form of its hydrochloride salt.

Stereochemistry []

Remifentanil is a achiral mixture.

Pharmacology

ATC Classification

In the nervous system (N) remifentanil acts as a anesthetic (N01), anesthetics, general (N01A), opioid anesthetic (N01AH) and remifentanil (N01AH06).^[1]

Metabolism

Subjective effects []

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

bonzi / Remifentanil []

Legal status []

Australia: Remifentanil is a S8 substance.
Brazil: Remifentanil is a A1 substance.^[3]
Canada: Remifentanil is a Schedule I substance.
Germany: Remifentanil is a Anlage III substance.
United Kingdom: Remifentanil is a Class A substance.
United States: Remifentanil is a Schedule I under the "Controlled Substances Act (CSA)".

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 60815, Remifentanil. Accessed April 16, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/60815
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Remifentanil. UNII: P10582JYYK. Global Substance Registration System. Accessed April 16, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/P10582JYYK
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed April 16, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992

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