{"ATC Code":["N01AH06","N - Nervous system","N01 - Anesthetics","N01A - Anesthetics, general","N01AH - Opioid anesthetics","N01AH06 - Remifentanil","QN - Nervous system","QN01 - Anesthetics","QN01A - Anesthetics, general","QN01AH - Opioid anesthetics","QN01AH06 - Remifentanil"],"Absorption, Distribution and Excretion":"Remifentanil is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes.","Aliases":["Remifentanil","Remifentanyl","ramifentanyl","GI 87084X","Ultiva-","Remifentanilo","IDS-NR-005","4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester","methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate","CHEBI:8802","Dtxsid00157826","1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester","4-(methoxycarbonyl)-4-((1-oxopropyl)phenylamino)-1-piperidinepropanoic acid methyl ester","remifentanilum","3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester","Dtxcid6080317","N01AH06","Ultiva","Unii-p10582jyyk","Remifentanil;","DEA No. 9739","CHEMBL1005","Schembl36652","Bidd:gt0029","GTPL7292","HSDB 8377","GLXC-06399","DB00899","SB17331","DB-042144","NS00007756","C08021","D08473","L001266","1-Piperidinepropanoic acid, 4-(methoxycarbonyl)-4-[(1-oxopropyl)phenylamino]-, methyl ester","methyl 1-(3-methoxy-3-oxopropyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate"],"Biological Half-Life":"1-20 minutes","CAS":"132875-61-7","ChemicalClasses":["amino acid"],"Chirality":"achiral","ChiralityAminoAcid":true,"Classes":["Opioid"],"Color/Form":"Oil","Drug Classes":["Breast Feeding","Lactation","Milk, Human","Analgesics, Opioid","Narcotics","Anesthetics, Intravenous","Opiates"],"Drug Indication":"For use during the induction and maintenance of general anesthesia.","Drug Warnings":"/BOXED WARNING/ WARNING: ADDICTION, ABUSE, AND MISUSE: Ultiva exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing Ultiva.","EliminationHalfLife":"1 – 20 minutes","Esters":[],"European Community (EC) Number":"685-601-1","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":20,"Value":{"StringWithMarkup":[{"String":"P10582JYYK"}]}},{"Name":"Active Moiety","ReferenceNumber":20,"Value":{"StringWithMarkup":[{"String":"REMIFENTANIL"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":20,"Value":{"StringWithMarkup":[{"String":"Mechanisms of Action [MoA] - Full Opioid Agonists"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":20,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Opioid Agonist"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":20,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-60815","Length":12,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Remifentanil"},{"Extra":"CID-60815","Length":12,"Start":62,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/remifentanil"}],"String":"Remifentanil is an Opioid Agonist. The mechanism of action of remifentanil is as a Full Opioid Agonist."}]}}],"Formating":[],"HMDB ID":"HMDB0015036","HeavyAtomCount":27,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Analgesics, Opioid; Narcotics; Anesthetics, Intravenous; Opiates","IUPACName":"methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate","InChI":"InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3","InChIKey":"ZTVQQQVZCWLTDF-UHFFFAOYSA-N","Interactions":"A patient who manifested signs of serotonin syndrome during an intravenous anesthetic with remifentanil and propofol is presented. The patient displayed lower extremity clonus, nystagmus, and diaphoresis. At the time of surgery, the patient was being treated with fluoxetine (a selective serotonin reuptake inhibitor). A presumptive diagnosis of serotonin syndrome was made intraoperatively and all opioids were discontinued. His symptoms resolved in the Postanesthesia Care Unit without incident.","KEGG Entries":[{"Id":"D01177","Interactions":[],"Synonyms":["Remifentanil hydrochloride","Ultiva"]},{"Id":"D08473","Interactions":[],"Synonyms":["Remifentanil","Ultiva"]},{"Id":"D01177","Interactions":[],"Synonyms":["Remifentanil hydrochloride","Ultiva"]},{"Id":"D08473","Interactions":[],"Synonyms":["Remifentanil","Ultiva"]}],"MeSH Headers":[{"Id":"M0194769","Link":"https://id.nlm.nih.gov/mesh/M0194769.html","Name":"Remifentanil","Ref":60},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":62},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":86},{"Id":"M0001068","Link":"https://id.nlm.nih.gov/mesh/M0001068.html","Name":"Analgesics, Opioid","Ref":87}],"MeSH Pharmacological Classification":[{"Id":"M0001068","Link":"https://id.nlm.nih.gov/mesh/M0001068.html","Name":"Analgesics, Opioid","Ref":87}],"Mechanism of Action":"Remifentanil is a \u0026micro;-opioid agonist with rapid onset and peak effect, and short duration of action. The \u0026micro;-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone.","Melting Point":"Crystals from methanol + ether. MP: 212-214 °C /Remifentanil hydrochloride/","Metabolism/Metabolites":"By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases.","MolecularFormula":"C\u003csub\u003e20\u003c/sub\u003eH\u003csub\u003e28\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e5\u003c/sub\u003e","MolecularWeight":"376.4 g/mol","Pharmacodynamics":"Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Remifentanil in humans has a rapid blood-brain equilibration half-time of 1 \u0026plusmn; 1 minutes (mean \u0026plusmn; SD) and a rapid onset of action.","Physical Description":"Solid","PubChemId":60815,"Record Description":["Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia. Remifentanil is used as an opioid analgesic that has a rapid onset and rapid recovery time. It has been used effectively during craniotomies, spinal surgery, cardiac surgery, and gastric bypass surgery. While opiates function similarly, with respect to analgesia, the pharmacokinetics of remifentanil allows for quicker post-operative recovery.","WIKIPEDIA|FENTANYL ANALOGUES"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"57845","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Remifentanil","Name":"Remifentanil","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q417902","Name":"Remifentanil","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00899","Name":"Remifentanil","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/60815","Name":"Remifentanil","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=132875-61-7","Name":"Remifentanil","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015036","Name":"Remifentanil","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C08021","Name":"Remifentanil","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/P10582JYYK","Name":"Remifentanil","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID00157826","Name":"Remifentanil","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 60815, Remifentanil. Accessed April 16, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/60815\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/60815\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Remifentanil. UNII: P10582JYYK. Global Substance Registration System. Accessed April 16, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/P10582JYYK\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/P10582JYYK\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed April 16, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC","SaltData":[{"AcidCount":1,"Amine":"Remifentanil","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","RName":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 163.06 102.257\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h164v103H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m139.186 64.611-15.008 2.65M124.178 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