Nikethamide

Nikethamide

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	178.23 g/mol ^[1]
Density	1.058 to 1.066 at 77 °F (NTP, 1992) g/cm³ ^[1]
Melting point	75 to 79 °F (NTP, 1992) ^[1]
Boiling point	565 to 572 °F at 760 mmHg (some decomposition) (NTP, 1992) ^[1]
Solubility	greater than or equal to 100 mg/mL at 73 °F (NTP, 1992) ^[1]
Predicted LogP	0.3 ^[1]

Structural Identifiers []
Molecular formula	C₁₀H₁₄N₂O ^[1]
IUPAC name	N,N-diethylpyridine-3-carboxamide ^[1]
SMILES	CCN(CC)C(=O)C1=CN=CC=C1 ^[1]
InChI	InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 ^[1]
InChIKey	NCYVXEGFNDZQCU-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	0.5 h

Nikethamide (also known as N,N-Diethylnicotinamide, Nikethamide, N,n-diethylnicotinamide, 59-26-7, Nicethamide, Nikethyl, Niquetamida, Nicethamidum, Carditonic or Diaethylamidum acidi nicotinici) is a stimulant substance of the pyridine class.

Chemistry

Stereochemistry []

Nikethamide is a achiral mixture.

Pharmacology

ATC Classification

In the respiratory system (R) nikethamide acts

Metabolism

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 5497, N,N-Diethylnicotinamide. Accessed February 17, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5497
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Nikethamide. UNII: 368IVD6M32. Global Substance Registration System. Accessed February 17, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/368IVD6M32

Anodyne