{"ATC Code":["R - Respiratory system","R07 - Other respiratory system products","R07A - Other respiratory system products","R07AB - Respiratory stimulants","R07AB02 - Nikethamide","QR - Respiratory system","QR07 - Other respiratory system products","QR07A - Other respiratory system products","QR07AB - Respiratory stimulants","QR07AB02 - Nikethamide"],"Abbreviation":[],"Aliases":["N,N-Diethylnicotinamide","Nikethamide","N,n-diethylnicotinamide","59-26-7","Nicethamide","Nikethyl","Niquetamida","Nicethamidum","Carditonic","Diaethylamidum acidi nicotinici","NSC-130820","Dtxsid9046524","368IVD6M32","Dtxcid7026524","Corethamid","Nizethamid","Diethylnicotinamid","Nicotinic Diethylamide","Nikethamidum","Diethylamide, Nicotinic","R07AB02","200-418-5","Anacardone","Coramine","3-Pyridinecarboxamide, N,N-diethyl-","Carbamidal","Corvotone","Nicorine","Pyricardyl","Corvin","Niamine","Anacordone","Astrocar","Cardamine","Cardiamid","Cardimon","Cordiamin","Corediol","Corvitol","Dynacoryl","Inicardio","Nicetamide","Nikardin","Stimulin","Ventramine","Coracon","Cormed","Cormid","Eucoran","Nikorin","Camphozone","Canfodiamina","Cardiamide","Cardiamina","Cardiamine","Coraetamidum","Coraethamide","Coraethamidum","Cordiamine","Corethamide","Dynamicarde","Nicordamin","Nicotinic acid diethylamide","Niketamide","Niketharol","Niketilamid","Procardine","Salvacorin","Stellamine","Cardiagen","Citocor","Coralept","Coravita","Corazone","Cordiamid","Corditon","Cordynil","Corespin","Coretone","Cormotyl","Cornotone","Corotonin","Corovit","Corvitan","Corywas","Danamine","Dinacoryl","Elitone","Hansacor","Kardiamid","Kardonyl","Kordiamin","Leptamin","Mediamid","Nicoryl","Niketamid","Percoral","Procorman","Reformin","Rehormin","Salvacard","Sancora","Solyacord","Stiminol","Tonocor","Corivo","Nicor","Diethylnicotinamide","Diethyl-Nicotamide","Nisetamide","Dietilamide-Carbopiridina","Diaethyl-nicotinamid","Pyridine-3-carboxydiethylamide","N,N-Diethyl-3-pyridinecarboxamide","Vasazol","Pyridine-3-carboxylic acid diethylamide","β-Pyrimidum","Nicotinamide, N,N-diethyl-","Ni-Cor","Mfcd00006386","Diethylamid kyseliny nikotinove","Ncgc00166026-01","Nicaethamidum","Nicotinamide,N-diethyl-","Wln: t6nj cvn2\u00262","3-Pyridinecarboxamide,N-diethyl-","N,N-diethyl-3-pyridylcarboxamide","Nicetamida","Coramin","Einecs 200-418-5","NSC 130820","Brn 0005743","Nickethamide","Niketamine","Ecoran","Unii-368ivd6m32","AI3-01438","Coractiv N","Nikethamide CRS","N,N-diethyl nicotinamide","Mls004773905","Schembl246456","N,N-Diethylnicotinamide, 99%","orb2281212","Schembl4818530","Chembl2104607","Schembl23036843","Schembl29754232","HY-B1280R","3-(N,N-Diethylcarbamoyl)pyridine","Chebi:134814","HMS3264D18","HMS3886G05","HMS5083N20","Pharmakon1600-01506157","HY-B1280","MSK10210","Tox21_112295","Bdbm50248014","EBC-03427","NSC-62103","NSC760377","s4887","SBB056987","Akos003607578","CCG-213619","DB13655","FD31942","MB00187","NSC-169863","NSC-760377","Cas-59-26-7","Ncgc00166026-02","AC-12043","AC-31724","AS-48195","Smr000059067","DB-053354","D0514","NS00008862","ST50308250","D07408","F19704","Ab01563149_01","En300-6492955","Q902548","Sr-01000939653","Sr-01000939653-2","Brd-k91544578-001-03-8","Z31723199","Nikethamide, European Pharmacopoeia (EP) Reference Standard","InChI=1/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H"],"Boiling Point":"565 to 572 °F at 760 mmHg (some decomposition) (NTP, 1992)","CAS":"59-26-7","Chemical Classes":"Nicotinic Acids","ChemicalClasses":["pyridine"],"Chirality":"achiral","Classes":["Stimulant"],"Density":"1.058 to 1.066 at 77 °F (NTP, 1992) g/cm\u003csup\u003e3\u003c/sup\u003e","EliminationHalfLife":"0.5 h","Esters":[],"European Community (EC) Number":"200-418-5","Flash Point":"235 °F (NTP, 1992)","Formating":[],"HMDB ID":"HMDB0255604","HeavyAtomCount":13,"Human Drugs":"Pharmaceuticals","IUPACName":"N,N-diethylpyridine-3-carboxamide","InChI":"InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3","InChIKey":"NCYVXEGFNDZQCU-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0014858","Link":"https://id.nlm.nih.gov/mesh/M0014858.html","Name":"Nikethamide","Ref":54},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":56},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":74},{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulants","Ref":75},{"Id":"M0005136","Link":"https://id.nlm.nih.gov/mesh/M0005136.html","Name":"Convulsants","Ref":76}],"MeSH Pharmacological Classification":[{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulant","Ref":75},{"Id":"M0005136","Link":"https://id.nlm.nih.gov/mesh/M0005136.html","Name":"Convulsant","Ref":76}],"Melting Point":"75 to 79 °F (NTP, 1992)","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO","MolecularWeight":"178.23 g/mol","Physical Description":"Nicethamid appears as clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. (NTP, 1992)","PubChemId":5497,"Records":{"UNII":{"Impurities":[]}},"RefChem":"854147","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Nikethamide","Name":"Nikethamide","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q902548","Name":"Nikethamide","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB13655","Name":"Nikethamide","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5497","Name":"Nikethamide","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=59-26-7","Name":"Nikethamide","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0255604","Name":"Nikethamide","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D07408","Name":"Nikethamide","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/368IVD6M32","Name":"Nikethamide","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9046524","Name":"Nikethamide","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5497, N,N-Diethylnicotinamide. Accessed February 17, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5497\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5497\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Nikethamide. UNII: 368IVD6M32. Global Substance Registration System. Accessed February 17, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/368IVD6M32\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/368IVD6M32\u003c/a\u003e"],"SMILES":"CCN(CC)C(=O)C1=CN=CC=C1","SaltData":[],"Salts":[],"Scheduling":[],"Solubility":"greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 81.285 51.813\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h82v52H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m1.038 25.935 13.2-7.618M14.238 18.317l10.043 5.801M27.434 29.789l-.002 11.39M27.432 41.179l-13.199 7.618M30.588 24.119l10.046-5.798\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m39.415 19.025.002-12.023M41.853 19.025l.002-12.022\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m39.417 7.002-.001 6.011M41.855 7.003l-.001 6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m40.634 18.321 13.197 7.622\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M53.831 25.943v15.24M56.269 27.352v12.423\"/\u003e\u003c/g\u003e\u003cpath d=\"m53.831 41.183 10.055 5.801\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m70.193 46.984 10.054-5.801M68.974 44.872l8.835-5.097\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m70.193 46.984 5.027-2.9M68.974 44.872l4.418-2.549\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M80.247 41.183v-15.24\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m80.247 25.943-13.208-7.62M77.809 27.352l-10.77-6.214\"/\u003e\u003c/g\u003e\u003cpath d=\"m53.831 25.943 13.208-7.62\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M29.375 28.389h-.72l-2.619-4.066h-.03l.03.595q.023.357.023.732v2.739h-.565v-4.9h.714l2.608 4.054h.029l-.017-.327-.024-.476q-.006-.262-.006-.482v-2.769h.577z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M42.896 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881T40.651.56q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M68.98 51.253h-.721l-2.619-4.066h-.03l.03.595q.024.357.024.733v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578z\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m24.281 24.118-5.022-2.9M27.434 29.789l-.001 5.695M30.588 24.119l5.023-2.899M63.886 46.984l-5.027-2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":{"Cognitive Effects":["Analysis enhancement","Ego inflation","Focus enhancement","Increased music appreciation","Motivation enhancement","Thought acceleration","Wakefulness","Disinhibition","Suggestibility suppression","Cognitive euphoria","Compulsive redosing","Mania"],"Physical Effects":["Increased libido","Stamina enhancement","Stimulation","Appetite suppression","Dehydration","Dry mouth","Restless legs","Shakiness","Teeth grinding","Abnormal heartbeat","Increased blood pressure","Increased heart rate","Vasoconstriction"],"Visual Effects":[]},"Title":"Nikethamide","UNII":"368IVD6M32","Wikidata":"Q902548","Wikipedia":"Nikethamide","XLogP":0.3}