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Dexmedetomidine

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Dexmedetomidine
Dexmedetomidine
Salts
[]
Dexmedetomidine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
Conformer structure via 3Dmol.js
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Physical properties
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200.28 g/mol [1]
SolubilityFreely soluble in water [1]
3.1 [1]
Structural Identifiers
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C13H16N2 [1]
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole [1]
CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C [1]
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 [1]
InChIKeyCUHVIMMYOGQXCV-NSHDSACASA-N [1]
Pharmacokinetics[]
Elimination half-life2 – 4 hours

Dexmedetomidine (also known as Dexmedetomidine, Dexmedetomidina, Dexmedetomidinum, MPV 1440, MPV-1440, Medetomidine, (s)-, 4-((S)-α,2,3-Trimethylbenzyl)imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, CHEBI:4466 or Dtxsid10873388) is a substance of the phenethylamine class.

Chemistry

Salts []

Dexmedetomidine is typically found in the form of its hydrochloride salt.

 []

Dexmedetomidine is a absolute mixture.

Pharmacology

In the () dexmedetomidine acts as a dexmedetomidine (), hypnotics and sedative (), other hypnotics and sedative () and psycholeptic ().[1]

Metabolism

Interactions []

CYP2A6inhibition
CYP2C19induction / inhibition
CYP2D6induction / inhibition

Subjective effects []

bonzi / Dexmedetomidine []

Legal status []

  • Australia: Dexmedetomidine is a S4 substance.[3]
  • Brazil: Dexmedetomidine is a C1 substance.
  • United States: Dexmedetomidine is a prescription only substance.
  • European Union: Dexmedetomidine is a prescription only substance.

See also []

  • Substituted phenethylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5311068, Dexmedetomidine. Accessed April 16, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5311068

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dexmedetomidine. UNII: 67VB76HONO. Global Substance Registration System. Accessed April 16, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/67VB76HONO

    3. DEXMEDETOMIDINE FRESENIUS (Fresenius Kabi Australia Pty Ltd). Accessed April 16, 2026. https://www.tga.gov.au/resources/prescription-medicines-registrations/dexmedetomidine-fresenius-fresenius-kabi-australia-pty-ltd