Anodyne

Bupropion

Salts []
Hydrobromide

Hydrochloride

Maleate

Molecular structure via molpic based on CDK

Conformer []

Conformer structure via JSmol

Physical properties []
Molecular mass	239.74 g/mol ^[1]
Appearance	Pale yellow oil ^[1]
Melting point	233-234 °C ^[1]
Boiling point	52 °C ^[1]
Solubility	Very hygroscopic and susceptible to decomposition ^[1]
Predicted LogP	3.2 ^[1]

Structural Identifiers []
Molecular formula	C₁₃H₁₈ClNO ^[1]
IUPAC name	2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one ^[1]
SMILES	CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C ^[1]
InChI	InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 ^[1]
InChIKey	SNPPWIUOZRMYNY-UHFFFAOYSA-N ^[1]

Bupropion

Bupropion (also known as Amfebutamone, Amfebutamon, amfebutamonum, Amfebutamona, Elontril, Bupropion slow release, bupropione, Bupropion extended release, α-(tert-butylamino)-m-chloropropiophenone or 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone) is a stimulant substance of the cathinone class.

Chemistry

Salts []

Bupropion is typically found in the form of its hydrobromide, hydrochloride and maleate salts.

Stereochemistry []

Bupropion is a racemic mixture of the enantiomers

Stereoisomers
(R)-Bupropion (S)-Bupropion

Pharmacology

Bupropion acts as a prodrug for:

Active metabolites []
Hydroxybupropion Threohydrobupropion Erythrohydrobupropion

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Anodyne Usernotes []
0xea / Bupropion^{[hydrochloride]} via Oral and Intravenous	Paradoxical Pharmacology; Caused Panic attack

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 444, Bupropion. Accessed July 19, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/444
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Bupropion. UNII: 01ZG3TPX31. Global Substance Registration System. Accessed July 19, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/01ZG3TPX31