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Bupropion

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Bupropion
Bupropion
Salts
[]
Bupropion hydrobromide
Generated by the Chemistry Development Kit (http://github.com/cdk)
Bupropion hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Bupropion maleate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
Conformer structure via 3Dmol.js
Enable javascript to view conformer structure via 3Dmol.js
Physical properties
[]
239.74 g/mol [1]
AppearancePale yellow oil [1]
Melting point233-234 °C [1]
Boiling point52 °C [1]
SolubilityVery hygroscopic and susceptible to decomposition [1]
3.2 [1]
Structural Identifiers
[]
C13H18ClNO [1]
2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one [1]
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C [1]
InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 [1]
InChIKeySNPPWIUOZRMYNY-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-lifeBupropion: alpha: 0.5 – 1.04beta: 11 hHydroxybupropion: 20 hThreohydrobupropion: 37 hErythrohydrobupropion: 33 h
Dosing[]
Intravenous
[]
Light≤ 43.1 mg(3x - 30%)
Common43.1 - 50 mg(4x - 40%)
Strong50 - 57.5 mg
Heavy57.5 - 74.4 mg(1x - 10%)
Extreme74.4 mg +(2x - 20%)
Oral
[]
Light≤ 200 mg(94x - 40.7%)
Common200 - 300 mg(136x - 58.9%)
Strong300 mg
Heavy300 mg
Extreme300 mg +(1x - 0.4%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Bupropion (also known as Amfebutamone, Amfebutamon, amfebutamonum, Amfebutamona, Elontril, Bupropion slow release, bupropione, Bupropion extended release, α-(tert-butylamino)-m-chloropropiophenone or NSC-758686) is a stimulant substance of the cathinone class.

Chemistry

Salts []

Bupropion is typically found in the form of its hydrobromide, hydrochloride and maleate salts.

 []

Bupropion is a racemic mixture of the .

(R)-BupropionGenerated by the Chemistry Development Kit (http://github.com/cdk)
(S)-BupropionGenerated by the Chemistry Development Kit (http://github.com/cdk)
Stereoisomer enumberation with rdkit

Pharmacology

In the () bupropion acts as a antidepressant (), bupropion (), other antidepressant () and psychoanaleptic ().[1]

Metabolism

Bupropion acts as a for:

Metabolic pathways []

Subjective effects []

class / Stimulant
alina / Bupropion []
Routes:
  • Oral (150 - 300mg)
Pilz / Bupropion []
Routes:
  • Oral (150.0mg)
Salts:
  • Hydrochloride
Indication:
emily / Bupropion []
Routes:
  • Oral (150 - 300mg)
0xea / Bupropion []
Routes:
  • Oral (150mg)
  • Intravenous (300mg)
Salts:
  • Hydrochloride
Effects:

Experience reports

Erowid

There are currently 26 experience reports involving bupropion on : []

 []

  • Australia: Bupropion is a S4 substance.[3]
  • Brazil: Bupropion is a C1 substance.
  • Canada: Bupropion is a prescription only substance.
  • United Kingdom: Bupropion is a prescription only substance.
  • United States: Bupropion is a prescription only substance.
  • European Union: Bupropion is a prescription only substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 444, bupropion. Accessed May 11, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/444

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Bupropion. UNII: 01ZG3TPX31. Global Substance Registration System. Accessed May 11, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/01ZG3TPX31

  3. TGA eBS – Product and Consumer Medicine Information Licence. Accessed May 11, 2026. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2013-PI-01138-1