Anodyne| Thiopental | |
|---|---|
| Salts [] | |
|---|---|
| Thiopental sodium | |
| Molecular structure via molpic |
| Physical properties [] | |
|---|---|
| Molecular mass | 242.34 g/mol [1] |
| Predicted LogP | 2.9 [1] |
| Decomposition | When heated to decomposition it emits very toxic fumes of /nitrogen and sulfur oxides/. [1] |
| Solubility | 3.98e-02 g/L [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C11H18N2O2S [1] |
| IUPAC name | 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione [1] |
| SMILES | CCCC(C)C1(C(=O)NC(=S)NC1=O)CC [1] |
| InChI | InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16) [1] |
| InChIKey | IUJDSEJGGMCXSG-UHFFFAOYSA-N [1] |
| Dosing | |
|---|---|
| Elimination half-life | 5.5[4]–26 hours[5] |
| Duration of action | 5 – 10 minutes |
Thiopental
Thiopental (also known as Thiopental, thiopental, Pentothiobarbital, Penthiobarbital, Thiopentone, Thiopentobarbital, Thiomebumal, Thionembutal, Thiopentobarbitone or 76-75-5) is a substance of the thiobarbiturate class.
Chemistry
Salts []
Thiopental is typically found in the form of its sodium salt.
Stereochemistry []
Thiopental is a racemic mixture of the optical stereoisomers:
| Stereoisomers |
|---|
Legal status
- Australia: Thiopental is a S4 substance.
- Brazil: Thiopental is a B1 substance.[3]
- Canada: Thiopental is a Schedule IV substance.
- United States: Thiopental is a Schedule I under the "Controlled Substances Act (CSA)".
- United Kingdom: Thiopental is a Class B substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 3000715, Thiopental. Accessed July 13, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/3000715
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Thiopental. UNII: JI8Z5M7NA3. Global Substance Registration System. Accessed July 13, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/JI8Z5M7NA3
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 13, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992
Russo H, Brès J, Duboin MP, Roquefeuil B. Pharmacokinetics of thiopental after single and multiple intravenous doses in critical care patients. European Journal of Clinical Pharmacology. 49(1–2):127–37.
Morgan DJ, Blackman GL, Paull JD, Wolf LJ. Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology. June 1, 1981; 54(6):474–80.