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Phendimetrazine

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Phendimetrazine
Phendimetrazine
Salts
[]
Phendimetrazine succinate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Phendimetrazine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Phendimetrazine tartrate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Phendimetrazine fumarate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Rotamer
[]
Conformer structure via 3Dmol.js
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Physical properties
[]
191.27 g/mol [1]
AppearanceWhite powder [1]
OdorOdorless [1]
TasteBitter [1]
Melting point208 °C [1]
Boiling point122-124 °C at 8 mm Hg; 134-135 °C at 12 mm Hg [1]
DecompositionWhen heated to decomp it emits very toxic fumes of /nitrogen oxides and hydrogen chloride/. /Phendimetrazine hydrochloride/ [1]
SolubilityFree sol in water; very slightly sol in alcohol; practically insol in chloroform and ether. [1]
1.9 [1]
Structural Identifiers
[]
C12H17NO [1]
(2S,3S)-3,4-dimethyl-2-phenylmorpholine [1]
C[C@H]1[C@@H](OCCN1C)C2=CC=CC=C2 [1]
InChI=1S/C12H17NO/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3/t10-,12+/m0/s1 [1]
InChIKeyMFOCDFTXLCYLKU-CMPLNLGQSA-N [1]
Pharmacokinetics[]
Elimination half-life19 – 24 hours

Phendimetrazine (also known as Mephenmetrazine, Fendimetrazina, Phendimetrazinum, Sedafamen, (2S,3S)-3,4-Dimethyl-2-phenylmorpholine, 3,4-Dimethyl-2-phenyltetrahydro-1,4-oxazine, Morpholine, 3,4-dimethyl-2-phenyl-, (2S-trans)-, Morpholine, 3,4-dimethyl-2-phenyl-, (+)-, NSC-169187 or Dtxsid1023447) is a substance of the 2-phenylmorpholine class.

Chemistry

Salts []

Phendimetrazine is typically found in the form of its succinate, hydrochloride, tartrate and fumarate salts.

 []

Phendimetrazine is a absolute mixture.

Pharmacology

Metabolism

Phendimetrazine acts as a for:

Metabolic pathways []

Experience reports []

There are currently 2 experience reports involving phendimetrazine on :

 []

  • Brazil: Phendimetrazine is a B2 substance.[3]
  • Canada: Phendimetrazine is a Schedule IV substance.
  • United States: Phendimetrazine is a Schedule I under the "Controlled Substances Act (CSA)".
  • Germany: Phendimetrazine is a Anlage II substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 30487, phendimetrazine. Accessed May 11, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/30487

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Phendimetrazine. UNII: AB2794W8KV. Global Substance Registration System. Accessed May 11, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/AB2794W8KV

  3. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed May 11, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992