{"Abbreviation":"","Actives":["Phenmetrazine","Pseudophenmetrazine"],"Aliases":["Mephenmetrazine","Fendimetrazina","Phendimetrazinum","Sedafamen","(2S,3S)-3,4-Dimethyl-2-phenylmorpholine","3,4-Dimethyl-2-phenyltetrahydro-1,4-oxazine","Morpholine, 3,4-dimethyl-2-phenyl-, (2S-trans)-","Morpholine, 3,4-dimethyl-2-phenyl-, (+)-","(2S,3S)-3,4-dimethyl-2-phenyl-morpholine","211-204-6","3,4-Dimethyl-2-phenylmorpholine","2-Phenyl-3,4-dimethylmorpholine","Adphen","Bontril","(2R-trans)-3,4-Dimethyl-2-phenylmorpholine","Morpholine, 3,4-dimethyl-2-phenyl-, (2S,3S)-","DB01579","C07904","D08347"],"Biological Half-Life":"19-24 hours","Boiling Point":"122-124 °C at 8 mm Hg; 134-135 °C at 12 mm Hg","CAS":"634-03-7","ChEBI":"CHEBI:8059","ChEMBL":"CHEMBL1615439","ChemicalClasses":["phenylmorpholine"],"Chirality":"absolute","Color/Form":"White powder","Decomposition":"When heated to decomp it emits very toxic fumes of /nitrogen oxides and hydrogen chloride/. /Phendimetrazine hydrochloride/","Drug Indication":"Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.","Drug Warnings":"An increased prevalence of abnormal  cardiac valve function, primarily aortic regurgitation, was found on echocardiographic evaluation in patients receiving phentermine in combination with either dexfenfluramine  or fenfluramine, both of which act to suppress appetite by increasing  serotonergic function; however, an increased prevalence of abnormal cardiac valve function also has been found in patients receiving dexfenfluramine or fenfluramine alone, and the role of phentermine  in producing the cardiotoxic effect is uncertain; because of the severity of these cardiovascular effects and because the safety and efficacy of other appetite suppressant combinations have not been established, combined use is not recommended; also, the safety and efficacy of combining as selective serotonin reuptake inhibitor (SSRI), which enhances  serotonergic function, with a sympathomimetic appetite suppressant have not been established and combined use is not recommended. /Appetite suppressants, sympathomimetic/","EINECS":"211-204-6","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"211-204-6","FDA Pharmacological Classification":"AB2794W8KV","Formating":[],"HeavyAtomCount":14,"Human Drugs":"Human drug -\u003e Discontinued","IUPACName":"(2S,3S)-3,4-dimethyl-2-phenylmorpholine","InChI":"InChI=1S/C12H17NO/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3/t10-,12+/m0/s1","InChIKey":"MFOCDFTXLCYLKU-CMPLNLGQSA-N","MeSH Pharmacological Classification":"A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)","Melting Point":"208 °C","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eNO","MolecularWeight":"191.27 g/mol","Odor":"Odorless","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Phendimetrazine is a phenylalkylamine sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance has been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known as ''anorectics or anorexigenics.\" It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. Other central nervous system actions or metabolic effects, may be involved.","PubChemId":30487,"Record Description":["LiverTox|Weight loss agent|Obesity|Sympathomimetic amine"],"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Phendimetrazine","Name":"Phendimetrazine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01579","Name":"Phendimetrazine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/30487","Name":"Phendimetrazine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1615439","Name":"Phendimetrazine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8059","Name":"Phendimetrazine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=634-03-7","Name":"Phendimetrazine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07904","Name":"Phendimetrazine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/AB2794W8KV","Name":"Phendimetrazine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023447","Name":"Phendimetrazine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 30487, Phendimetrazine. Accessed July 19, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/30487\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/30487\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Phendimetrazine. UNII: AB2794W8KV. Global Substance Registration System. Accessed July 19, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/AB2794W8KV\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/AB2794W8KV\u003c/a\u003e"],"SMILES":"C[C@H]1[C@@H](OCCN1C)C2=CC=CC=C2","SaltData":[{"AcidCount":1,"AmineCount":1,"Formula":"C(=C/C(=O)O)\\C(=O)O","Name":"fumarate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 169.548 55.414\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h170v56H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M54.158 31.518h-.7L51.712 46.75h4.201z\" class=\"bond\"/\u003e\u003cpath d=\"m53.808 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stroke=\"none\" d=\"M42.877 8.662q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M68.943 26.342h-.72l-2.62-4.066h-.029l.029.595q.024.357.024.732v2.739h-.565v-4.9h.714l2.608 4.054h.029l-.018-.327-.023-.476q-.006-.262-.006-.483v-2.768h.577z\" class=\"atom\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m40.618 12.586-.001 5.659M43.896 6.77l4.959-2.866\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m67.003 20.042.001-5.695M63.849 25.714l-5.021 2.902M70.156 25.712l5.019 2.897\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m127.135 23.897 13.198 7.62M127.135 26.713l10.759 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