{"Absorption, Distribution and Excretion":"Peak plasma levels occur within 1 to 3 hours. Absorption is usually complete by 4 to 6 hours.","Actives":["Phenmetrazine","Pseudophenmetrazine"],"Aliases":["Mephenmetrazine","Fendimetrazina","Phendimetrazinum","Sedafamen","(2S,3S)-3,4-Dimethyl-2-phenylmorpholine","3,4-Dimethyl-2-phenyltetrahydro-1,4-oxazine","Morpholine, 3,4-dimethyl-2-phenyl-, (2S-trans)-","Morpholine, 3,4-dimethyl-2-phenyl-, (+)-","NSC-169187","Dtxsid1023447","(2S,3S)-3,4-dimethyl-2-phenyl-morpholine","Dtxcid001771131","211-204-6","3,4-Dimethyl-2-phenylmorpholine","2-Phenyl-3,4-dimethylmorpholine","Adphen","Bontril","DEA No. 1615","NSC 169187","HSDB 3381","(2R-trans)-3,4-Dimethyl-2-phenylmorpholine","Einecs 211-204-6","Unii-ab2794w8kv","Morpholine, 3,4-dimethyl-2-phenyl-, (2S,3S)-","Schembl598950","CHEBI:8059","Chembl1615439","GTPL14332","Akos006281399","DB01579","NS00006244","C07904","D08347"],"Biological Half-Life":"19-24 hours","Boiling Point":"122-124 °C at 8 mm Hg; 134-135 °C at 12 mm Hg","CAS":"634-03-7","Chemical Classes":"Pharmaceutical","ChemicalClasses":["2-phenylmorpholine"],"Chirality":"absolute","Color/Form":"White powder","Decomposition":"When heated to decomp it emits very toxic fumes of /nitrogen oxides and hydrogen chloride/. /Phendimetrazine hydrochloride/","Drug Indication":"Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.","Drug Warnings":"An increased prevalence of abnormal  cardiac valve function, primarily aortic regurgitation, was found on echocardiographic evaluation in patients receiving phentermine in combination with either dexfenfluramine  or fenfluramine, both of which act to suppress appetite by increasing  serotonergic function; however, an increased prevalence of abnormal cardiac valve function also has been found in patients receiving dexfenfluramine or fenfluramine alone, and the role of phentermine  in producing the cardiotoxic effect is uncertain; because of the severity of these cardiovascular effects and because the safety and efficacy of other appetite suppressant combinations have not been established, combined use is not recommended; also, the safety and efficacy of combining as selective serotonin reuptake inhibitor (SSRI), which enhances  serotonergic function, with a sympathomimetic appetite suppressant have not been established and combined use is not recommended. /Appetite suppressants, sympathomimetic/","EliminationHalfLife":"19 – 24 hours","Erowid Experience Reports":[{"Author":"bry-bry","Id":53238,"Title":"Excellent Wake-Aid"},{"Author":"Ketaman","Id":102376,"Title":"Blissful Rush"}],"Esters":[],"European Community (EC) Number":"211-204-6","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":17,"Value":{"StringWithMarkup":[{"String":"AB2794W8KV"}]}},{"Name":"Active Moiety","ReferenceNumber":17,"Value":{"StringWithMarkup":[{"String":"PHENDIMETRAZINE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":17,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Appetite Suppression"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":17,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Increased Sympathetic Activity"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":17,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Sympathomimetic Amine Anorectic"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":17,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-30487","Length":15,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Phendimetrazine"},{"Extra":"CID-30487","Length":15,"Start":80,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/phendimetrazine"}],"String":"Phendimetrazine is a Sympathomimetic Amine Anorectic. The physiologic effect of phendimetrazine is by means of Appetite Suppression, and Increased Sympathetic Activity."}]}}],"Formating":[],"HeavyAtomCount":14,"IUPACName":"(2S,3S)-3,4-dimethyl-2-phenylmorpholine","InChI":"InChI=1S/C12H17NO/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3/t10-,12+/m0/s1","InChIKey":"MFOCDFTXLCYLKU-CMPLNLGQSA-N","Interactions":"Concurrent use /of other CNS stimulation-producing medications or thyroid hormones with appetite suppressants/ may increase the CNS stimulant effects of either these medications or the appetite suppressant. /Appetite suppressants, sympathomimetic/","KEGG Entries":[{"Id":"D02080","Interactions":[],"Synonyms":["Phendimetrazine tartrate","Bontril","Statobex"]},{"Id":"D08347","Interactions":[],"Synonyms":["Phendimetrazine"]},{"Id":"D08348","Interactions":[],"Synonyms":["Phendimetrazine hydrochloride","Antapentan"]}],"MeSH Headers":[{"Id":"M0263376","Link":"https://id.nlm.nih.gov/mesh/M0263376.html","Name":"phendimetrazine","Ref":36},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":38},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":57},{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulants","Ref":58}],"MeSH Pharmacological Classification":[{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulant","Ref":58}],"Mechanism of Action":"Phendimetrazine may act in a similar way to amphetamines in that it activates the alpha-adrenergic system to induce an appetite suppressive and metabolic increase effect. The drug also acts as a norepinephrine-dopamine releasing agent (NDRA). It can bind to and reverse the NET.","Melting Point":"208 °C","Metabolism/Metabolites":"Approximately 30% of a given dose of phendimetrazine is metabolized into phenmetrazine, which may account for part of its anorectic effect, and probably also influences abuse potential; individuals who metabolise a greater proportion of phendimetrazine into phenmetrazine are more likely to develop problems with dependence and addiction","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eNO","MolecularWeight":"191.27 g/mol","Odor":"Odorless","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Phendimetrazine is a phenylalkylamine sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance has been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known as ''anorectics or anorexigenics.\" It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. Other central nervous system actions or metabolic effects, may be involved.","PubChemId":30487,"Record Description":["LiverTox|Weight loss agent|Obesity|Sympathomimetic amine"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"56407","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Phendimetrazine","Name":"Phendimetrazine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q1649219","Name":"Phendimetrazine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01579","Name":"Phendimetrazine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/30487","Name":"Phendimetrazine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=634-03-7","Name":"Phendimetrazine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07904","Name":"Phendimetrazine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/AB2794W8KV","Name":"Phendimetrazine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023447","Name":"Phendimetrazine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 30487, phendimetrazine. Accessed May 11, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/30487\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/30487\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Phendimetrazine. UNII: AB2794W8KV. Global Substance Registration System. Accessed May 11, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/AB2794W8KV\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/AB2794W8KV\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed May 11, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"C[C@H]1[C@@H](OCCN1C)C2=CC=CC=C2","SaltData":[{"AcidCount":1,"Amine":"Phendimetrazine","AmineCount":1,"Formula":"C(CC(=O)O)C(=O)O","Name":"succinate","RName":"succinate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 169.548 55.408\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h170v56H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M54.158 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