Pazinaclone
| Pazinaclone | |
|---|---|
 | |
| Molecular structure via molpic based on CDK |
| Physical properties [] | |
|---|---|
| Molecular mass | 478.9 g/mol [1] |
| Predicted LogP | 2.8 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C25H23ClN4O4 [1] |
| IUPAC name | 2-(7-chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one [1] |
| SMILES | C1CN(CCC12OCCO2)C(=O)CC3C4=CC=CC=C4C(=O)N3C5=NC6=C(C=C5)C=CC(=N6)Cl [1] |
| InChI | InChI=1S/C25H23ClN4O4/c26-20-7-5-16-6-8-21(28-23(16)27-20)30-19(17-3-1-2-4-18(17)24(30)32)15-22(31)29-11-9-25(10-12-29)33-13-14-34-25/h1-8,19H,9-15H2 [1] |
| InChIKey | DPGKFACWOCLTCA-UHFFFAOYSA-N [1] |
Pazinaclone (also known as DN-2327, A-77000, DN2327, 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(((1,4-dioxa-8-azaspiro(4.5)dec-8-yl)carbonyl)methyl)-1-isoindolinone, 8-((2-(7-Chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl)acetyl)-1,4-dioxa-8-azaspiro(4.5)decane, A77000, pazinaclonum, Dtxcid80817375, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-((1,4-dioxa-8-azaspiro(4.5)dec-8-yl)carbonylmethyl)isoindolin-1-one or pazinaclona) is a
Chemistry
Stereochemistry []
Pazinaclone is a racemic mixture of the enantiomers.
| Stereoisomerism |
|---|
| Stereoisomer enumberation with rdkit |
Druglikeness
Lipinski's rule of five
Pazinaclone matches Lipinski's rule of five.See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 59743, Pazinaclone. Accessed June 12, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/59743
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pazinaclone. UNII: MHK03047IJ. Global Substance Registration System. Accessed June 12, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/MHK03047IJ