Anodyne

Fenethylline

Salts []
Hydrochloride

Molecular structure via molpic based on CDK

Conformer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	341.4 g/mol ^[1]
Melting point	227-229 ^[1]
Predicted LogP	1.4 ^[1]

Structural Identifiers []
Molecular formula	C₁₈H₂₃N₅O₂ ^[1]
IUPAC name	1,3-dimethyl-7-[2-(1-phenylpropan-2-ylamino)ethyl]purine-2,6-dione ^[1]
SMILES	CC(CC1=CC=CC=C1)NCCN2C=NC3=C2C(=O)N(C(=O)N3C)C ^[1]
InChI	InChI=1S/C18H23N5O2/c1-13(11-14-7-5-4-6-8-14)19-9-10-23-12-20-16-15(23)17(24)22(3)18(25)21(16)2/h4-8,12-13,19H,9-11H2,1-3H3 ^[1]
InChIKey	NMCHYWGKBADVMK-UHFFFAOYSA-N ^[1]

Fenethylline

Fenethylline (also known as Fenetylline, Phenethylline, Amfetyline, Captagon, Fenetyllin, Amphetaminoethyltheophylline, Theophyllineethylamphetamine, Fenetylinum, Fenetilina or Fitton) is a codrug, prodrug and stimulant substance of the amphetamine class.

Chemistry

Salts []

Fenethylline is typically found in the form of its hydrochloride salt.

Stereochemistry []

Fenethylline is a racemic mixture of the enantiomers

Stereoisomers
(R)-Fenethylline (S)-Fenethylline

Pharmacology

Fenethylline acts as a codrug for:

Active metabolites []
Amphetamine Theophylline

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 19527, Fenethylline. Accessed July 19, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/19527
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Fenethylline. UNII: YZ0N7VL5R3. Global Substance Registration System. Accessed July 19, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/YZ0N7VL5R3