Anodyne

Dimethocaine

Salts []
Dimethocaine salicylate

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	278.39 g/mol ^[1]
Predicted LogP	3.1 ^[1]

Structural Identifiers []
Molecular formula	C₁₆H₂₆N₂O₂ ^[1]
IUPAC name	[3-(diethylamino)-2,2-dimethylpropyl] 4-aminobenzoate ^[1]
SMILES	CCN(CC)CC(C)(C)COC(=O)C1=CC=C(C=C1)N ^[1]
InChI	InChI=1S/C16H26N2O2/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13/h7-10H,5-6,11-12,17H2,1-4H3 ^[1]
InChIKey	OWQIUQKMMPDHQQ-UHFFFAOYSA-N ^[1]

Toxicity []
LD_Lo	Mouse: - subcutaneous: 380 mg/kg - intravenous: 40 mg/kg Rabbit: - subcutaneous: 150 mg/kg - intravenous: 150 mg/kg Guinea pig: - subcutaneous: 200 mg/kg Frog: - parenteral: 860 mg/kg

Dimethocaine

Dimethocaine (also known as 3-(Diethylamino)-2,2-dimethylpropyl 4-aminobenzoate, (3-Diethylamino-2,2-dimethyl)propyl 4-aminobenzoat, 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, 4-aminobenzoate, RefChem:134182, Larocaine, 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, p-aminobenzoate, 3-Diethylamino-2,2-dimethylpropyl 4-Aminobenzoate, 2-Dicyclohexylphosphino-2',6'-bis(N,N-dimethylamino)biphenyl; 2'-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethylbiphenyl-2,6-diamine, 4-Aminobenzoesaeure-3-diethylamino-2,2-dimethylproplylester or 1-Propanol, 2-[(diethylamino)methyl]-2-methyl-, 1-(4-aminobenzoate)) is a sodium channel blocker and stimulant substance of the carboxylic acid class.

Chemistry

Salts []

Dimethocaine is typically found in the form of its salicylate salt.

Stereochemistry []

Dimethocaine is a achiral mixture

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Anodyne Usernotes []
0xea / Dimethocaine^{[freebase][citrate]} via Intravenous and Vaporized	strong numbing effect both in veins and mouth; mild euphoria; pleasant vaporized

Legal status []

Germany: Dimethocaine is a Anlage II substance.
United Kingdom: Dimethocaine is a PSA substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 7177, Dimethocaine. Accessed October 7, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/7177
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dimethocaine. UNII: R3L4A6GOWZ. Global Substance Registration System. Accessed October 7, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/R3L4A6GOWZ