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Dextromethorphan

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DXM
Dextromethorphan
[]
Molecular structure via molpic based on CDK
[]
Conformer structure via 3Dmol.js
Enable javascript to view conformer structure via 3Dmol.js
Physical properties
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271.4 g/mol [1]
AppearanceWhite to slightly yellow crystalline powder [1]
OdorOdorless [1]
Melting point122-124 [1]
DecompositionWhen heated to decomposition it emits toxic fumes of /nitrogen oxides/. [1]
SolubilityPractically insoluble in water [1]
3.4 [1]
Structural Identifiers
[]
C18H25NO [1]
(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene [1]
CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC [1]
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1 [1]
InChIKeyMKXZASYAUGDDCJ-NJAFHUGGSA-N [1]
Pharmacokinetics[]
Elimination half-life2 – 4 hours (extensive metabolizers); 24 hours (poor metabolizers)[3]
Duration of action3 – 8 hours
Dosing[]
Oral
[]
Light≤ 27.5 mg(6x - 25%)
Common27.5 - 30 mg(9x - 37.5%)
Strong30 - 68.8 mg(3x - 12.5%)
Heavy68.8 - 244.5 mg(3x - 12.5%)
Extreme244.5 mg +(3x - 12.5%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Dextromethorphan (also known as Methorphan, Δ-Methorphan, morphan, methorfan, metorfano, methorphane, Albutussin, Destrometerfano, methorphanum or BA 2666)

Chemistry

Salts []

Dextromethorphan is typically found in the form of its hydriodide, hydrochloride, salicylate and hydrobromide salts.

 []

Dextromethorphan is a absolute mixture.

Pharmacology

In the () dextromethorphan acts

Metabolism

Interactions []

induction / inhibition
induction / inhibition

Subjective effects []

x86pup / Dextromethorphan []
Routes:
  • Oral
  • Sublingual
magnus / Dextromethorphan []
Routes:
  • Oral
0xea / Dextromethorphan []
Routes:
  • Oral (66mg)
  • Insufflated
  • Intravenous
  • Vaporized (50mg)
Salts:
  • Hydrobromide
Notes:
  • effective dosing not reached
  • might have worsened previous stimulant psychosis

Experience reports []

There are currently 25+ experience reports involving dextromethorphan on :

 []

  • Australia: Dextromethorphan is a S2 substance.
  • United Kingdom: Dextromethorphan is a P substance.
  • United States: Dextromethorphan is a OTC substance.
  • Canada: Dextromethorphan is a OTC substance.
  • United Nations: Dextromethorphan is a Unscheduled substance.

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5360696, dextromethorphan. Accessed May 7, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5360696

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dextromethorphan. UNII: 7355X3ROTS. Global Substance Registration System. Accessed May 7, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7355X3ROTS

  3. Balminil DM, Benylin DM (dextromethorphan) dosing, indications, interactions, adverse effects, and more. WebMD. Accessed May 7, 2026. http://reference.medscape.com/drug/balminil-dm-benylin-dm-dextromethorphan-343401#showall}