{"ATC Code":["QR - Respiratory system","QR05 - Cough and cold preparations","QR05D - Cough suppressants, excl. combinations with expectorants","QR05DA - Opium alkaloids and derivatives","QR05DA09 - Dextromethorphan","R - Respiratory system","R05 - Cough and cold preparations","R05D - Cough suppressants, excl. combinations with expectorants","R05DA - Opium alkaloids and derivatives","R05DA09","R05DA09 - Dextromethorphan"],"Abbreviation":["DXM"],"Absorption, Distribution and Excretion":"A 30mg oral dose of dextromethorphan  reaches a Cmax of 2.9 ng/mL, with a Tmax of 2.86 h, and an AUC of 17.8 ng\\*h/mL.","Adverse Effects":"Adverse effects from cough suppressants are rare. The most common are nausea and gastrointestinal discomfort, while drowsiness and dizziness can also occur.","Aliases":["Methorphan","Δ-Methorphan","morphan","methorfan","metorfano","methorphane","Albutussin","Destrometerfano","methorphanum","BA 2666","Balminil DM","methorphan","3-Methoxy-17-methyl-9α,13α,14α-morphinan","Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-","DXM","BA-2666","CHEBI:4470","3-Methoxy-N-methylmorphinon","NSC-751452","Dtxsid3022908","cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4α-iminoethanophenanthren","3-methoxy-17-methyl-9α,13α,14α-morphinan","RoboTablets","Delsym","Soothe Comfort I Cough Syrup","Hydrochloride, Dextromethorphan","Soothe Comfort II Cough Syrup","Dtxcid202908","Soothe Comfort I Cough Syrup Original","Soothe Comfort II Cough Syrup Herbal Mint","LIBI AIR VIRLAZA Dextromethorphan Cough Suppressant","(1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo(7.5.3.01,10.02,7)heptadeca-2(7),3,5-triene","204-752-2","Nodex","HSDB 3056","metorphan","3-Methoxy-17-methylmorphinan","( )-3-Methoxy-N-methylmorphinon","Einecs 204-752-2","Brn 0088549","Unii-7355x3rots","Calmylin","Medicon","Romilar","Tusilan","9α,13α,14α-Morphinan, 3-methoxy-17-methyl-","Prestwick0_000359","Prestwick1_000359","Prestwick2_000359","Prestwick3_000359","Lopac-D-2531","Epitope ID:549279","Racemethorphan","( )-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4α-iminoethanophenanthren","Schembl29949","BSPBio_000457","4-21-00-01367","Chembl52440","SPBio_002378","BPBio1_000503","GTPL6953","Schembl29357059","Chebi:92579","3-methoxy-n-methylmorphinan","(9α,13α,14α)-17-methyl-3-(methyloxy)morphinan","9-α,13-α,14-α-Morphinan, 3-methoxy-17-methyl-","HMS2090C08","LSM-2726","Morphinan, 3-methoxy-17-methyl-, (9-α,13-α,14-α)-","Bdbm50366613","methorphan, 1mg/ml in Methanol","Akos025311415","DB00514","FM36326","NSC 751452","Ncgc00015333-01","Ncgc00015333-02","3-Methoxy-17-methyl-9a,13a,14a-morphinan","NS00008569","(9a,13a,14a)-3-Methoxy-17-methylmorphinan","C06947","D03742","9-α,-14-α-3-Methoxy-17-methylmorphinan","3-Methoxy-17-methyl-9α,13α-morphinan","Brd-k33211335-004-01-7","Brd-k33211335-337-03-7","(9α,13α,14α)-3-Methoxy-17-methylmorphinan","Morphinan, 3-methoxy-17-methyl-, (9?,13?,14?)-","3-Methoxy-17-methylmorphinan-, (9α,13α,14α)- #","4-methoxy-12-methyl-12-azatetracyclo[9.3^1.10^.0^2.7^] heptadeca-2(7),3,5-triene","(1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene","(4aS,10S,10aS)-6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene","(4bS,8aS,9S)-3-methoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene","4NQ"],"Biological Half-Life":"Dextromethorphan has a half life of 3-30 hours.","CAS":"125-71-3","Chemical Classes":"Pharmaceutical","Chirality":"absolute","Color/Form":"White to slightly yellow crystalline powder","DBI-IGS":["Dextromethorphan"],"Decomposition":"When heated to decomposition it emits toxic fumes of /nitrogen oxides/.","Dosing Info":[{"Method":"Oral","Tiers":{"Common":{"Entries":9,"Lower":27.5,"Percentage":37.5,"Unit":"mg","Upper":30},"Extreme":{"Entries":3,"Lower":244.5,"Percentage":12.5,"Unit":"mg","Upper":244.5},"Heavy":{"Entries":3,"Lower":68.8,"Percentage":12.5,"Unit":"mg","Upper":244.5},"Light":{"Entries":6,"Lower":27.5,"Percentage":25,"Unit":"mg","Upper":27.5},"Strong":{"Entries":3,"Lower":30,"Percentage":12.5,"Unit":"mg","Upper":68.8}}}],"Drug Classes":["Breast Feeding","Lactation","Milk, Human","Antitussive Agents"],"Drug Indication":"Dextromethorphan is indicated in combination with [brompheniramine] and [pseudoephedrine] in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with [guaifenesin] as an over-the-counter product to relieve a cough. Dextromethorphan in combination with [quinidine] is indicated in the treatment of pseudobulbar affect.","Drug Warnings":"Administration of dextromethorphan may be associated with histamine release, and the drug should be used with caution in atopic children. Dextromethorphan also should be used with caution in sedated or debilitated patients and in patients confined to the supine position. Dextromethorphan should not be taken for persistent or chronic cough (e.g., with smoking, emphysema, asthma) or when coughing is accompanied by excessive secretions, unless directed by a clinician. If cough persists for longer than 1 week, tends to recur, or is accompanied by high fever, rash, or persistent headache, a clinician should be consulted.","DurationOfAction":"3 – 8 hours","EliminationHalfLife":"2 – 4 hours (extensive metabolizers); 24 hours (poor metabolizers)\u003ca href='#cite_note-3'\u003e\u003csup\u003e[3]\u003c/sup\u003e\u003c/a\u003e","Erowid Experience Reports":[{"Author":"Various","Id":1903,"Title":"Duds and Disappointments"},{"Author":"Ultiman","Id":57818,"Title":"Absolutely Nothing"},{"Author":"Pete","Id":9965,"Title":"No False Positive"},{"Author":"iMi","Id":6527,"Title":"Just Say No To Buckley's Mixture"},{"Author":"M.A","Id":28076,"Title":"Waste Of Time Because Nothing Happened"},{"Author":"Chromaxion","Id":79360,"Title":"Shape of Mind"},{"Author":"Sierra","Id":34655,"Title":"Brownie Tripping"},{"Author":"EC","Id":63376,"Title":"What a Let-Down"},{"Author":"Madhatter","Id":79010,"Title":"Absolut Fikshun"},{"Author":"Joey","Id":1906,"Title":"Smart Drug DXM"},{"Author":"Scott Taylor","Id":1899,"Title":"Continued Spatial And Mental Distortions"},{"Author":"alex","Id":60710,"Title":"Stupid Waste - Needed More For Big Effects"},{"Author":"D.W. Forbes","Id":1896,"Title":"Like a Serious Alcohol Buzz"},{"Author":"David McIntyre","Id":1894,"Title":"Foreign Surroundings"},{"Author":"Onward","Id":59323,"Title":"Is This My Life?"},{"Author":"Letting_Go","Id":58720,"Title":"Morning After Trip"},{"Author":"Garrett","Id":107106,"Title":"Light Dose Gave More of a Sedative Effect"},{"Author":"Ubermensch","Id":57714,"Title":"Can Amph Tolerance be Reduced/Eliminated?"},{"Author":"fict","Id":15375,"Title":"Electronic Opiate"},{"Author":"Vic","Id":65079,"Title":"Analgesic Application of Smaller Dose"},{"Author":"MMX","Id":16369,"Title":"Not What I Had Expected"},{"Author":"Xherrus","Id":21290,"Title":"Tapping into the Mainframe"},{"Author":"Byron","Id":23667,"Title":"30-40 Urine Drug Tests in the Last Two Years"},{"Author":"DXMman","Id":4929,"Title":"Insufflating DXM Powder"},{"Author":"Eva","Id":24819,"Title":"False-Positive for PCP on Drug Test"},{"Author":"rconcolor","Id":110535,"Title":"Enough to Skip One Dose of My Medication"}],"Esters":[],"European Community (EC) Number":"204-752-2","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"String":"7355X3ROTS"}]}},{"Name":"Active Moiety","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"String":"DEXTROMETHORPHAN"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-22880","Length":20,"Start":54,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/N-methyl-D-aspartate"}],"String":"Established Pharmacologic Class [EPC] - Uncompetitive N-methyl-D-aspartate Receptor Antagonist"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Sigma-1 Agonist"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-22880","Length":4,"Start":43,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/NMDA"}],"String":"Mechanisms of Action [MoA] - Uncompetitive NMDA Receptor Antagonists"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"String":"Mechanisms of Action [MoA] - Sigma-1 Receptor Agonists"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":26,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-5360696","Length":16,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Dextromethorphan"},{"Extra":"CID-22880","Length":20,"Start":37,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/N-methyl-D-aspartate"},{"Extra":"CID-5360696","Length":16,"Start":126,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/dextromethorphan"},{"Extra":"CID-22880","Length":4,"Start":166,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/NMDA"}],"String":"Dextromethorphan is an Uncompetitive N-methyl-D-aspartate Receptor Antagonist and Sigma-1 Agonist. The mechanism of action of dextromethorphan is as an Uncompetitive NMDA Receptor Antagonist and Sigma-1 Receptor Agonist."}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":58,"Value":{"StringWithMarkup":[{"String":"DEXTROMETHORPHAN"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":58,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-22880","Length":20,"Start":47,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/N-methyl-D-aspartate"},{"Extra":"CID-22880","Length":4,"Start":132,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/NMDA"}],"String":"Sigma-1 Receptor Agonists [MoA]; Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]; Sigma-1 Agonist [EPC]; Uncompetitive NMDA Receptor Antagonists [MoA]"}]}}],"Formating":[],"Health Effects":"Hypertension, shallow respiration. Dextromethorphan can cause other gastrointestinal disturbances. [Wikipedia]","HeavyAtomCount":20,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Antitussive Agents","IUPACName":"(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene","InChI":"InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1","InChIKey":"MKXZASYAUGDDCJ-NJAFHUGGSA-N","Interactions":"Because cases of apparent serotonin syndrome, including 2 fatalities, have been reported in patients receiving dextromethorphan and monoamine oxidase (MAO) inhibitors concomitantly, dextromethorphan preparations should not be used in patients receiving these drugs or for 2 weeks after discontinuing them.","KEGG Entries":[{"Id":"D00848","Interactions":[{"Action":"inhibition","Target":"CYP2D6"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan hydrobromide","Dextromethorphan hydrobromide hydrate","Benylin DM"]},{"Id":"D03742","Interactions":[{"Action":"inhibition","Target":"CYP2D6"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan"]},{"Id":"D03744","Interactions":[{"Action":"inhibition","Target":"CYP2D6"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan polistirex","Delsym"]},{"Id":"D04340","Interactions":[{"Action":"induction","Target":"CYP3A4"},{"Action":"inhibition","Target":"CYP2D6"},{"Action":"inhibition","Target":"CYP3A4"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan hydrobromide and potassium cresolsulfonate","Medicon"]},{"Id":"D00848","Interactions":[{"Action":"inhibition","Target":"CYP2D6"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan hydrobromide","Dextromethorphan hydrobromide hydrate","Benylin DM"]},{"Id":"D03742","Interactions":[{"Action":"inhibition","Target":"CYP2D6"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan"]},{"Id":"D03744","Interactions":[{"Action":"inhibition","Target":"CYP2D6"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan polistirex","Delsym"]},{"Id":"D04340","Interactions":[{"Action":"induction","Target":"CYP3A4"},{"Action":"inhibition","Target":"CYP2D6"},{"Action":"inhibition","Target":"CYP3A4"},{"Action":"induction","Target":"CYP2D6"}],"Synonyms":["Dextromethorphan hydrobromide and potassium cresolsulfonate","Medicon"]}],"MeSH Headers":[{"Id":"M0006138","Link":"https://id.nlm.nih.gov/mesh/M0006138.html","Name":"Dextromethorphan","Ref":85},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":87},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":115},{"Id":"M0001516","Link":"https://id.nlm.nih.gov/mesh/M0001516.html","Name":"Antitussive Agents","Ref":116},{"Id":"M0028006","Link":"https://id.nlm.nih.gov/mesh/M0028006.html","Name":"Excitatory Amino Acid Antagonists","Ref":117}],"MeSH Pharmacological Classification":[{"Id":"M0001516","Link":"https://id.nlm.nih.gov/mesh/M0001516.html","Name":"Antitussive Agent","Ref":116},{"Id":"M0028006","Link":"https://id.nlm.nih.gov/mesh/M0028006.html","Name":"Excitatory Amino Acid Antagonist","Ref":117}],"Mechanism of Action":"Dextromethorphan is a low-affinity uncompetitive NMDA antagonist and sigma-1 receptor agonist. It is also an antagonist of α3/β4 nicotinic receptors. However, the mechanism by which dextromethorphan's receptor agonism and antagonism translate to a clinical effect is not well understood.","Melting Point":"122-124","Metabolism/Metabolites":"Dextromethorphan can be N-demethylated to 3-methoxymorphinan by CYP3A4, CYP2D6, and CYP2C9 or O-demethylated to dextrorphan by CYP2D6 and CYP2C9. Dextrorphan is N-demethylated by CYP3A4 and CYP2D6, while 3-methoxymorphinan is O-demethylated by CYP2D6. Both are metabolized to form 3-hydroxymorphinan. Dextrorphan and 3-hydroxymorphinan are both O-glucuronidated or O-sulfated.","MolecularFormula":"C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e25\u003c/sub\u003eNO","MolecularWeight":"271.4 g/mol","Non-Human Toxicity Values":"LD50 Mouse sc 112 mg/kg","Odor":"Odorless","Opticalactivity":"( + )","Pharmacodynamics":"Dextromethorphan is an opioid-like molecule indicated in combination with other medication in the treatment of coughs and pseudobulbar affect. It has a moderate therapeutic window, as intoxication can occur at higher doses. Dextromethorphan has a moderate duration of action. Patients should be counselled regarding the risk of intoxication.","PubChemId":5360696,"Records":{"UNII":{"Impurities":[]}},"RefChem":"6417","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Dextromethorphan","Name":"Dextromethorphan","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q407781","Name":"Dextromethorphan","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00514","Name":"Dextromethorphan","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5360696","Name":"Dextromethorphan","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=125-71-3","Name":"Dextromethorphan","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C06947","Name":"Dextromethorphan","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/7355X3ROTS","Name":"Dextromethorphan","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022908","Name":"Dextromethorphan","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5360696, dextromethorphan. Accessed May 7, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5360696\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5360696\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dextromethorphan. UNII: 7355X3ROTS. Global Substance Registration System. Accessed May 7, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7355X3ROTS\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/7355X3ROTS\u003c/a\u003e","Balminil DM, Benylin DM (dextromethorphan) dosing, indications, interactions, adverse effects, and more. WebMD. Accessed May 7, 2026. \u003ca href=http://reference.medscape.com/drug/balminil-dm-benylin-dm-dextromethorphan-343401#showall}\u003ehttp://reference.medscape.com/drug/balminil-dm-benylin-dm-dextromethorphan-343401#showall}\u003c/a\u003e"],"SMILES":"CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC","SaltData":[{"AcidCount":1,"Amine":"Dextromethorphan","AmineCount":1,"Formula":"I","Name":"hydriodide","RName":"hydriodide","Title":"Dextromethorphan hydriodide","UNII":"086F8ZEM77"},{"AcidCount":1,"Amine":"Dextromethorphan","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","RName":"hydrochloride","Title":"Dextromethorphan hydrochloride","UNII":"351KFH969D"},{"AcidCount":1,"Amine":"Dextromethorphan","AmineCount":1,"Formula":"O=C(O)c1ccccc1O","Name":"salicylate","RName":"salicylate","Title":"Dextromethorphan salicylate","UNII":"B2F298X1AJ"},{"AcidCount":1,"Amine":"Dextromethorphan","AmineCount":1,"Formula":"Br","Name":"hydrobromide","RName":"hydrobromide","Title":"Dextromethorphan hydrobromide","UNII":"9D2RTI9KYH"}],"Salts":["hydriodide","hydrochloride","salicylate","hydrobromide"],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S2 substance"},{"gov":"United Kingdom","ref":[],"schedule":"P substance"},{"gov":"United States","ref":[],"schedule":"OTC substance"},{"gov":"Canada","ref":[],"schedule":"OTC substance"},{"gov":"United Nations","ref":[],"schedule":"Unscheduled substance"}],"Solubility":"Practically insoluble in water","Stability/Shelf Life":"Stable under recommended storage conditions. /Dextromethorphan hydrobromide/","StereoisomerData":[],"Stereoisomers":[],"Therapeutic Uses":"Antitussive Agents; Excitatory Amino Acid Antagonists","Title":"Dextromethorphan","Toxicity Data":"LD50: 165 mg/kg (mice) (L1858)\nLD50: 350 mg/kg (rat) (L1858)\n","UNII":"7355X3ROTS","Wikidata":"Q407781","Wikipedia":"Dextromethorphan","XLogP":3.4}