Apomorphine
| Apomorphine | |
|---|---|
 |
| Salts [] | |
|---|---|
| Diapomorphine dihydrochloride | |
| Molecular structure via molpic based on CDK |
| Rotamer [] | |
|---|---|
| Conformer structure via 3Dmol.js |
| Physical properties [] | |
|---|---|
| Molecular mass | 267.32 g/mol [1] |
| Appearance | Hexagonal plates from chloroform+petroleum ether; rods from ether [1] |
| Melting point | 195 °C [1] |
| Decomposition | When heated to decomposition it emits highly toxic fumes of nitroxides. [1] |
| Solubility | MINUTE, WHITE OR GRAYISH WHITE, GLISTENING CRYSTALS OR WHITE POWDER; ODORLESS; SOLN ARE NEUTRAL TO LITMUS; LEVOROTATORY IN DIL ACID; 1 G SOL IN 50 ML WATER, IN ABOUT 50 ML ALCOHOL, & IN ABOUT 20 ML WATER @ 80 °C; PPT BY TANNIC ACID & OTHER ALKALOIDAL PRECIPITANTS & DECOMP BY OXIDIZING AGENTS. /HCL/ [1] |
| Predicted LogP | 2.3 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C17H17NO2 [1] |
| IUPAC name | (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol [1] |
| SMILES | CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O [1] |
| InChI | InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 [1] |
| InChIKey | VMWNQDUVQKEIOC-CYBMUJFWSA-N [1] |
| Pharmacokinetics[] | |
|---|---|
| Elimination half-life | 40 minutes |
| Duration of action | 60 – 90 min |
Apomorphine (also known as Apomorfin, Apomorphin, Ixense, R-(-)-Apomorphine, 6aβ-Aporphine-10,11-diol, Apomorphinum, 10,11-Dihydroxyaporphine, VR-040, Dtxsid8022614 or VR040) is a
Chemistry
Salts []
Apomorphine is typically found in the form of its dihydrochloride salt.
Stereochemistry []
Apomorphine is a absolute mixture.
Pharmacology
ATC Classification
In the genito urinary system and sex hormones (G) apomorphine acts In the nervous system (N) apomorphine acts as a anti (N04), apomorphine (N04BC07), dopamine agonist (N04BC) and dopaminergic agent (N04B).[1]Metabolism
Subjective effects []
| emily / Apomorphine [] | |
|---|---|
Routes:
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Legal status []
- Australia: Apomorphine is a S4 substance.[3]
- Canada: Apomorphine is a prescription only substance.
- United Kingdom: Apomorphine is a prescription only substance.
- United States: Apomorphine is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 6005, apomorphine. Accessed May 6, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/6005
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Apomorphine. UNII: N21FAR7B4S. Global Substance Registration System. Accessed May 6, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/N21FAR7B4S
Movapo Pod (Stada Pharmaceuticals Australia Pty Ltd). September 13, 2024. Accessed May 6, 2026. https://www.tga.gov.au/resources/prescription-medicines-registrations/movapo-pod-stada-pharmaceuticals-australia-pty-ltd