Thiopropamine

Thiopropamine

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	141.24 g/mol ^[1]
Predicted LogP	1.8 ^[1]

Structural Identifiers []
Molecular formula	C₇H₁₁NS ^[1]
IUPAC name	1-thiophen-2-ylpropan-2-amine ^[1]
SMILES	CC(CC1=CC=CS1)N ^[1]
InChI	InChI=1S/C7H11NS/c1-6(8)5-7-3-2-4-9-7/h2-4,6H,5,8H2,1H3 ^[1]
InChIKey	NYVQQTOGYLBBDQ-UHFFFAOYSA-N ^[1]

Thiopropamine (also known as Thiopropamine, 2-Thiopheneethanamine, α-methyl-, 1-(2-Thienyl)-2-propanamine, 1-(Thien-2-yl)propan-2-amine, 1-Methyl-2-(thien-2-yl)ethylamine, (1-Methyl-2-(thiophen-2-yl)ethyl)amine, Dtxsid80424381, α-Methyl-2-thiopheneethanamine, α-Methyl-2-thiopheneethylamine or Dtxcid10834010) is a stimulant substance of the thiopropamine class.

Chemistry

Stereochemistry []

Thiopropamine is a racemic mixture of the enantiomers.

Stereoisomerism
(R)-Thiopropamine (S)-Thiopropamine
Stereoisomer enumberation with rdkit

Subjective effects []

class / Stimulant

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Legal status []

Canada: Thiopropamine is a ^[3]
Germany: Thiopropamine is a Anlage I substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 6484133, 30433-93-3. Accessed May 6, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/6484133
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Thiopropamine. UNII: N60H4ZDD14. Global Substance Registration System. Accessed May 6, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/N60H4ZDD14
Drug Status Report - Thiopropamine. Accessed May 6, 2026. https://isomerdesign.com/Cdsa/HC/StatusDecisions/A-2013-01404%20-%20PDFs/C-Thienoamphetamine-2013-08-01.pdf

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