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Tadalafil

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Tadalafil
Tadalafil
Molecular structure via molpic based on CDK
Physical properties
[]
389.4 g/mol [1]
Melting point301-302 °C [1]
SolubilityPractically insoluble in water [1]
2.3 [1]
Structural Identifiers
[]
C22H19N3O4 [1]
(2R,8R)-2-(1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione [1]
CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36 [1]
InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 [1]
InChIKeyWOXKDUGGOYFFRN-IIBYNOLFSA-N [1]
Pharmacokinetics[]
Elimination half-life17.5 hours
Duration of action≤ 36 hours
Dosing[]
Oral
[]
Light≤ 12.5 mg(34x - 40%)
Common12.5 - 15 mg(13x - 15.3%)
Strong15 - 20 mg(34x - 40%)
Heavy20 mg
Extreme20 mg +(4x - 4.7%)
Statistically derived dosages via DBI-IGS
We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Tadalafil (also known as Tadalafil, Cialis, Ic351, ADCIRCA, IC 351, IC-351, Tadalafilo, Tadalafil mylan, Trans-tadalafil or CHEWTADZY) is a substance of the β-carboline and methylenedioxyphenethylamine class.

Chemistry

 []

Tadalafil is a achiral mixture.

Pharmacology

In the () tadalafil acts

Metabolism

Subjective effects []

emily / Tadalafil []
Routes:
  • Oral (13 - 20mg)
Pilz / Tadalafil []
Routes:
  • Oral (5mg)
Indication:

Legal status []

  • Australia: Tadalafil is a S4 substance.
  • United Kingdom: Tadalafil is a prescription only substance.[2]
  • United States: Tadalafil is a prescription only substance.
  • European Union: Tadalafil is a prescription only substance.

See also []

  • Substituted β-carbolines
  • Substituted methylenedioxyphenethylamines (MDxx)
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 110635, Tadalafil. Accessed April 11, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/110635

    2. Cialis 10mg film-coated tablets - Summary of Product Characteristics (SmPC). April 26, 2017. Accessed April 11, 2026. https://www.medicines.org.uk/emc/product/7431/smpc