Anodyne| Midazolam | |
|---|---|
 | |
| Molecular structure via molpic based on CDK |
| Conformer [] | |
|---|---|
| Conformer structure via JSmol | |
| Physical properties [] | |
|---|---|
| Molecular mass | 325.8 g/mol [1] |
| Appearance | Colorless crystals from ether/methylene chloride/ hexane [1] |
| Melting point | 161-164 [1] |
| Boiling point | 496.9±55.0 [1] |
| Decomposition | When heated to decomposition it emits toxic fumes of /hydrogen fluoride, hydrogen chloride and nitrogen oxides/. [1] |
| Solubility | 54mg/L [1] |
| Predicted LogP | 2.5 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C18H13ClFN3 [1] |
| IUPAC name | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine [1] |
| SMILES | CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F [1] |
| InChI | InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 [1] |
| InChIKey | DDLIGBOFAVUZHB-UHFFFAOYSA-N [1] |
| Dosing [] | |
|---|---|
| Elimination half-life | 1.5 – 2.5 hours |
| Duration of action | 1 - 6 hours |
Midazolam
Midazolam (also known as Buccolam, Midazolamum, 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, mezolam, Nayzilam, Midazolam civ, USL261, USL-261, 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin or 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine) is a
Chemistry
Salts []
Midazolam is typically found in the form of its hydrochloride and maleate salts.
Stereochemistry []
Midazolam is a achiral mixture
Legal status
- Australia: Midazolam is a S4 substance.
- Brazil: Midazolam is a B1 substance.[3]
- Canada: Midazolam is a Schedule IV substance.
- Germany: Midazolam is a prescription only/Anlage III substance.
- New Zealand: Midazolam is a Class C substance.
- United Kingdom: Midazolam is a prescription only substance.
- United States: Midazolam is a Schedule I under the "Controlled Substances Act (CSA)".
- European Union: Midazolam is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 4192, Midazolam. Accessed July 4, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/4192
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Midazolam. UNII: R60L0SM5BC. Global Substance Registration System. Accessed July 4, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/R60L0SM5BC
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 4, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992