Memantine
| Memantine | |
|---|---|
 |
| Salts [] | |
|---|---|
| Memantine hydrochloride | |
| Molecular structure via molpic based on CDK |
| Rotamer [] | |
|---|---|
| Conformer structure via 3Dmol.js |
| Physical properties [] | |
|---|---|
| Molecular mass | 179.30 g/mol [1] |
| Appearance | Oil [1] |
| Melting point | White to off white fine powder. Crystals from alcohol/ether. MP: 290-295 °C, also reported as 290-295 °C. Soluble in water. /Memantine hydrochloride/ [1] |
| Solubility | soluble in water [1] |
| Predicted LogP | 3.3 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C12H21N [1] |
| IUPAC name | 3,5-dimethyladamantan-1-amine [1] |
| SMILES | CC12CC3CC(C1)(CC(C3)(C2)N)C [1] |
| InChI | InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 [1] |
| InChIKey | BUGYDGFZZOZRHP-UHFFFAOYSA-N [1] |
| Pharmacokinetics[] | |
|---|---|
| Elimination half-life | 60 – 80 hours |
Memantine (also known as 1-Amino-3,5-dimethyladamantane, Memantina, 3,5-Dimethyl-1-adamantanamine, Memantinum, 3,5-Dimethyl-1-aminoadamantane, 1,3-Dimethyl-5-adamantanamine, nemdatine, Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, DRG-0267 or 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine) is a
Chemistry
Salts []
Memantine is typically found in the form of its hydrochloride salt.
Stereochemistry []
Memantine is a achiral mixture.
Pharmacology
ATC Classification
In the nervous system (N) memantine acts as a anti (N06D), memantine (N06DX01), other anti (N06DX) and psychoanaleptic (N06).[1]Metabolism
Subjective effects []
Experience reports []
There are currently 25+ experience reports involving memantine on Erowid:
- "Useful But Not Recreational" by rararagi
- "For Amphetamine Tolerance, Smoking Cessation" by lps
- "Not Too Stimulated but Energetic Enough" by Sonic
- "Quarantrip" by GlaciatedNorth
- "Mem-oires" by Mastronaut
- "Really Clean Disassociation" by AMA_Dragon
- "For Opioid Dependence, Maybe" by pharmnerd
- "Quarantrip, the Summer Sequel" by GlaciatedNorth
- "Almost Mushroomesque" by CaptainOubliz
- "This One Is My Favourite" by name
- "As Luck Would Have It" by EvDigital
- "Adventures in NMDA Receptor Antagonism" by viscosity
- "Alzheimer Medicine High" by stab
- "Down the Mem-Hole" by MadMastery
- "Feeling Normal At Last" by feelwheel
- "Free From Humanity" by BitBitt
- "Just the Kick in the Teeth I Was Looking For" by 180OnTheDVP
- "Follow-Up to '24-Hour HellTrip'" by 180OnTheDVP
- "24-Hour HellTrip" by 180OnTheDVP
- "A Few Words of Caution" by Lazyvegan
- "Being Disconnected From Reality" by itstingsandithurts
- "Good Day Later with a Double M-Hole" by Andex
- "A Dark Void I Call Home" by itstingsandithurts
- "Wintry Void" by nervewing
- "Relentless Dissociative Aphrodisiac" by Goddess Mode
Legal status []
- Australia: Memantine is a S4 substance.
- Brazil: Memantine is a C1 substance.[3]
- United Kingdom: Memantine is a prescription only substance.
- United States: Memantine is a prescription only substance.
- European Union: Memantine is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 4054, memantine. Accessed May 5, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/4054
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Memantine. UNII: W8O17SJF3T. Global Substance Registration System. Accessed May 5, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/W8O17SJF3T
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed May 5, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992