Mefentanyl

3-MF

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	350.5 g/mol ^[1]
Melting point	Crystals from isopropanol. MP: 272-8-273.6 °C /3-Methylfentanyl hydrochloride/ ^[1]
Predicted LogP	4.5 ^[1]

Structural Identifiers []
Molecular formula	C₂₃H₃₀N₂O ^[1]
IUPAC name	N-[3-methyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide ^[1]
SMILES	CCC(=O)N(C1CCN(CC1C)CCC2=CC=CC=C2)C3=CC=CC=C3 ^[1]
InChI	InChI=1S/C23H30N2O/c1-3-23(26)25(21-12-8-5-9-13-21)22-15-17-24(18-19(22)2)16-14-20-10-6-4-7-11-20/h4-13,19,22H,3,14-18H2,1-2H3 ^[1]
InChIKey	MLQRZXNZHAOCHQ-UHFFFAOYSA-N ^[1]

Mefentanyl (also known as 3-Methylfentanyl, 3-Methylfentanil, DEA No. 9813, N-(3-Methyl-1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide, Chebi:61092, Propanamide, N-(3-methyl-1-(2-phenylethyl)-4-piperidinyl)-N-phenyl-, QVU94XE61A, 3-methyl-fentanyl, N-(3-methyl-1-(2-phenylethyl)piperidin-4-yl)-N-phenylpropanamide or F-7209) is a opioid substance of the phenethylpiperidine class.

Chemistry

Stereochemistry []

Mefentanyl is a racemic mixture of the diastereomers.

Stereoisomerism
(5R,10S)-Mefentanyl (5S,10S)-Mefentanyl (5R,10R)-Mefentanyl (5S,10R)-Mefentanyl
Stereoisomer enumberation with rdkit

Subjective effects []

class / Opioid

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

Legal status []

Australia: Mefentanyl is a Unscheduled substance.
Brazil: Mefentanyl is a F1 substance.
Canada: Mefentanyl is a Schedule I substance.
New Zealand: Mefentanyl is a Unscheduled substance.
United Kingdom: Mefentanyl is a Class A substance.
Germany: Mefentanyl is a Anlage I substance.
United States: Mefentanyl is a Schedule I under the "Controlled Substances Act (CSA)".
United Nations: Mefentanyl is a Unscheduled substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 61996, Mefentanyl. Accessed May 25, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/61996

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