Anodyne

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Loprazolam
Loprazolam
Molecular structure via molpic based on CDK
Physical properties
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464.9 g/mol [1]
2.9 [1]
Structural Identifiers
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C23H21ClN6O3 [1]
(2Z)-6-(2-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one [1]
CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl [1]
InChI=1S/C23H21ClN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14- [1]
InChIKeyUTEFBSAVJNEPTR-RGEXLXHISA-N [1]
Dosing
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Elimination half-life6 – 12 hours

Loprazolam

Loprazolam (also known as Triazulenone, Loprazolamum, triazulenone, (Z)-isomer, Triazulenone, (z)-, Dormonoct, Ru-31158 free base, (Z)-6-(o-Chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-1H-imidazo(1,2-a)(1,4)benzodiazepin-1-one, HR 158, 1H-Imidazo(1,2-a)(1,4)benzodiazepin-1-one, 2,4-dihydro-6-(2-chlorophenyl)-2-((4-methyl-1-piperazinyl)methylene)-8-nitro- or (2Z)-6-(2-chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-1h-imidazo(1,2-a)(1,4)benzodiazepin-1-one) is a substance of the benzodiazepine class.

Chemistry

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Loprazolam is a achiral mixture

Legal status []

  • Brazil: Loprazolam is a B1 substance.[3]
  • Canada: Loprazolam is a Schedule IV substance.
  • Germany: Loprazolam is a prescription only/Anlage III substance.
  • United States: Loprazolam is a Schedule I under the "Controlled Substances Act (CSA)".

See also []

  • Substituted benzodiazepines (benzos)
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 3033860, Loprazolam. Accessed July 4, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/3033860

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Loprazolam. UNII: 759N8462G8. Global Substance Registration System. Accessed July 4, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/759N8462G8

    3. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 4, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992