Flumazenil

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	303.29 g/mol ^[1]
Melting point	201-203 °C ^[1]
Solubility	1.04e+00 g/L ^[1]
Predicted LogP	1 ^[1]

Structural Identifiers []
Molecular formula	C₁₅H₁₄FN₃O₃ ^[1]
IUPAC name	ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate ^[1]
SMILES	CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C ^[1]
InChI	InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 ^[1]
InChIKey	OFBIFZUFASYYRE-UHFFFAOYSA-N ^[1]

Dosing []
Elimination half-life	7–15 min (initial) 20–30 min (brain) 40–80 min (terminal)

Flumazenil

Flumazenil (also known as Flumazepil, Mazicon, Flumazenilum, Flumazenilo, Ro-15-1788, Flumazil, Ro15-1788, RO-151788, Ro 15-1788/000 or RO-1722) is a substance of the benzodiazepine class.

Chemistry

Stereochemistry []

Flumazenil is a achiral mixture

Legal status []

Australia: Flumazenil is a S4 substance.
Brazil: Flumazenil is a C1 substance.^[3]
Canada: Flumazenil is a prescription only substance.
United Kingdom: Flumazenil is a prescription only substance.
United States: Flumazenil is a prescription only substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 3373, Flumazenil. Accessed June 25, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/3373
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Flumazenil. UNII: 40P7XK9392. Global Substance Registration System. Accessed June 25, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/40P7XK9392
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed June 25, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992

Anodyne