Anodyne

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Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
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Hydriodide
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salicylate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Hydrobromide
Generated by the Chemistry Development Kit (http://github.com/cdk)
Hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
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Conformer structure via JSmol
Physical properties
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271.4 g/mol [1]
AppearanceWhite to slightly yellow crystalline powder [1]
OdorOdorless [1]
Melting point122-124 [1]
DecompositionWhen heated to decomposition it emits toxic fumes of /nitrogen oxides/. [1]
SolubilityPractically insoluble in water [1]
3.4 [1]
Structural Identifiers
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C18H25NO [1]
(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene [1]
CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC [1]
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1 [1]
InChIKeyMKXZASYAUGDDCJ-NJAFHUGGSA-N [1]
Dosing
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Elimination half-life2 – 4 hours (extensive metabolizers); 24 hours (poor metabolizers)[3]
Duration of action3 – 8 hours

Dextromethorphan

Dextromethorphan (also known as methorphan, Methorphan, Δ-Methorphan, morphan, methorfan, metorfano, methorphane, Albutussin, Destrometerfano or methorphanum) is a substance of the morphinan class.

Chemistry

Salts []

Dextromethorphan is typically found in the form of its hydriodide, salicylate, hydrobromide and hydrochloride salts.

 []

Dextromethorphan is a absolute mixture

Stereoisomers
(+)-DextromethorphanGenerated by the Chemistry Development Kit (http://github.com/cdk)
Generated by the Chemistry Development Kit (http://github.com/cdk)
Anodyne Usernotes
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0xea / Dextromethorphan[hydrobromide] via effective dosing not reached; might have worsened previous psychosis

Legal status []

  • Australia: Dextromethorphan is a S2 substance.
  • United Kingdom: Dextromethorphan is a P substance.
  • United States: Dextromethorphan is a OTC substance.
  • Canada: Dextromethorphan is a OTC substance.
  • United Nations: Dextromethorphan is a Unscheduled substance.

See also []

  • Substituted morphinans
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5360696, methorphan. Accessed July 7, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5360696

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. methorphan. UNII: 7355X3ROTS. Global Substance Registration System. Accessed July 7, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7355X3ROTS

    3. Balminil DM, Benylin DM (dextromethorphan) dosing, indications, interactions, adverse effects, and more. WebMD. Accessed July 7, 2025. http://reference.medscape.com/drug/balminil-dm-benylin-dm-dextromethorphan-343401#showall