4-Fluoromethylphenidate

4-FMPH

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	251.30 g/mol ^[1]
Predicted LogP	0.3 ^[1]

Structural Identifiers []
Molecular formula	C₁₄H₁₈FNO₂ ^[1]
IUPAC name	methyl 2-(4-fluorophenyl)-2-piperidin-2-ylacetate ^[1]
SMILES	COC(=O)C(C1CCCCN1)C2=CC=C(C=C2)F ^[1]
InChI	InChI=1S/C14H18FNO2/c1-18-14(17)13(12-4-2-3-9-16-12)10-5-7-11(15)8-6-10/h5-8,12-13,16H,2-4,9H2,1H3 ^[1]
InChIKey	XISBAJBPDVRSPG-UHFFFAOYSA-N ^[1]

Dosing[]

Insufflated []
Light	≤ 76.3 mg(1x - 50%)
Common	76.3 - 97.5 mg
Strong	97.5 - 118.8 mg
Heavy	118.8 - 131.5 mg
Extreme	131.5 mg +(1x - 50%)

Statistically derived dosages via DBI-IGS

We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

4-Fluoromethylphenidate (also known as 2-Piperidineacetic acid, α-(4-fluorophenyl)-, methyl ester, methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate, Diethyl 1-Phenyl-3-butene-1,1-dicarboxylate; Phenyl-2-propenyl-propanedioic Acid Diethyl Ester, Schembl13284388, Dtxsid001344817, DAC91015, EEC63133, EX-A5114, NS00018077 or threo-4-fluoromethylphenidate hydrochloride) is a stimulant substance of the phenidate class.

Chemistry

Stereochemistry []

4-Fluoromethylphenidate is a racemic mixture of the diastereomers.

Stereoisomerism
(4S,5S)-4-Fluoromethylphenidate (4R,5S)-4-Fluoromethylphenidate (4S,5R)-4-Fluoromethylphenidate (4R,5R)-4-Fluoromethylphenidate
Stereoisomer enumberation with rdkit

Subjective effects []

class / Stimulant

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

bonzi / 4-Fluoromethylphenidate []
Routes: Oral (10 - 30mg)

magnus / 4-Fluoromethylphenidate []
Routes: Oral Insufflated Salts: Hydrochloride Notes: methylphenidate's big brother very similar pharmacological effects longer duration, higher potency more recreational batches from spring 2023 were clean white crystals later batches 2024 changed the source/synthesis route changing the distribution of stereoisomers resulting in an off-white clumpy texture and drastically reduced potency

magnus / 4-Fluoromethylphenidate []

Routes:

Oral
Insufflated

Salts:

Hydrochloride

Notes:

methylphenidate's big brother
very similar pharmacological effects longer duration, higher potency more recreational
batches from spring 2023 were clean white crystals
later batches 2024 changed the source/synthesis route changing the distribution of stereoisomers resulting in an off-white clumpy texture and drastically reduced potency

Experience reports []

There are currently 16 experience reports involving 4-fluoromethylphenidate on Erowid:

Legal status []

Canada: 4-Fluoromethylphenidate is a Schedule III substance.
Germany: 4-Fluoromethylphenidate is a Neuer-Psychoaktiver-Stoff under the "Neue-psychoaktive-Stoffe-Gesetz (NpSG)".
United Kingdom: 4-Fluoromethylphenidate is a PSA substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 70876096, 1354631-33-6. Accessed May 8, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/70876096

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