2',5'-Dimethoxy-4'-bromo-fentanyl

N-(2C-B)-Fentanyl

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	475.4 g/mol ^[1]
Predicted LogP	4.9 ^[1]

Structural Identifiers []
Molecular formula	C₂₄H₃₁BrN₂O₃ ^[1]
IUPAC name	N-[1-[2-(4-bromo-2,5-dimethoxyphenyl)ethyl]piperidin-4-yl]-N-phenylpropanamide ^[1]
SMILES	CCC(=O)N(C1CCN(CC1)CCC2=CC(=C(C=C2OC)Br)OC)C3=CC=CC=C3 ^[1]
InChI	InChI=1S/C24H31BrN2O3/c1-4-24(28)27(19-8-6-5-7-9-19)20-11-14-26(15-12-20)13-10-18-16-23(30-3)21(25)17-22(18)29-2/h5-9,16-17,20H,4,10-15H2,1-3H3 ^[1]
InChIKey	IWJDXHKRMXYRFD-UHFFFAOYSA-N ^[1]

2',5'-Dimethoxy-4'-bromo-fentanyl (also known as N-(1-(4-Bromo-2,5-dimethoxyphenethyl)piperidin-4-yl)-N-phenylpropionamide, N-(2C-B) Fentanyl or 2',5'-Dimethoxy 4'-bromo fentanyl) is a opioid substance of the phenethylpiperidine class.

Chemistry

Stereochemistry []

2',5'-Dimethoxy-4'-bromo-fentanyl is a achiral mixture.

Subjective effects []

class / Opioid

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 165361468, 2',5'-Dimethoxy-4'-bromo-fentanyl. Accessed May 24, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/165361468
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 2',5'-Dimethoxy-4'-bromo-fentanyl. UNII: HGQ49M8PJ2. Global Substance Registration System. Accessed May 24, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/HGQ49M8PJ2

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